加味瓜蒌薤白半夏汤治疗冠状动脉粥样硬化性心脏病心绞痛临床观察

Clinical observation on treating angina pectoris from coronary atherosclerotic heart disease with the Gualou Xiebai decoction

目的:通过对加味瓜蒌薤白半夏汤联合鲁南欣康联合治疗气虚痰浊闭阻型冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛的临床观察,比较联合用药与鲁南欣康对心绞痛治疗的疗效。方法:从2014年11月-2018年6月到我院心内科、中医科就诊的气虚痰浊闭阻型冠心病心绞痛患者中随机抽取50例,随机分为对照组25例(鲁南欣康治疗)和治疗组25例(加味瓜蒌薤白半夏汤联合鲁南欣康治疗),比较两组的心电图改善疗效和中医证候积分及中医证候疗效。结果:对照组总有效率为56%,治疗组总有效率为80%,两组差异有统计学意义(P<0.05),且治疗组心电图改善有效率高于对照组;两组治疗前与治疗后在乏力、多痰、胸痛、心悸、气短、胸闷六指标差异均有统计学意义(P<0.05),且与治疗前比,两组治疗后该六指标均有缓解;经治疗后,两组的中医证候积分差异有统计学意义(P<0.05),且治疗组比对照组更有效;经治疗,对照组中医症候总有效率为68%,治疗组为96%,两组差异有统计学意义(P<0.05),且治疗组的有效率高于对照组。结论:加味瓜蒌薤白半夏汤联合鲁南欣康联合用药比鲁南欣康治疗冠心病心绞痛效果更好,是一项值得推广的治疗方法。

Objective:To compare efficacy of the Gualou Xiebai decoction(瓜蒌薤白半夏汤)plus Isosorbide Mononitrate on angina pectoris from coronary atherosclerotic heart disease.Methods:50 patients were randomly divided into the control group and the treatment group,25 cases in each.The control group took Isosorbide Mononitrate,and the treatment group received the Gualou Xiebai decoction more.Results:The total efficiency was 56%in the control group and 80%in the treatment group(P<0.05).The electrocardiogram improvement in the treatment group was higher than that in the control group.After the fatigue,sputum,chest pain,palpitations,shortness of breath,chest tightness,the six indicators showed statistically significant differences between before and after treatment(P<0.05),and compared with the pre-treatment,the six indicators were alleviated after treatment.The TCM syndrome scores in two groups showed a statistically significant difference after treatment(P<0.05).After treatment,the total efficiency in TCM syndrome was 68%in the control group,lower than 96%in the treatment group(P<0.05).Conclusion:The Gualou Xiebai decoction plus Isosorbide Mononitrate on angina pectoris from coronary atherosclerotic heart disease is more effective.