IL-6、IL-18与心房颤动的关系研究

Study on the Relationship Between Interleukin-6, Interleukin-18 and Atrial Fibrillation

目的:研究心房颤动患者血清白细胞介素-18、白细胞介素-6水平与心房颤动的关系。方法:选取2017年12月~2018年12月急诊内科及心血管内科收治的71例房颤患者,按其房颤持续时间分为阵发性房颤组11例、持续性房颤组23例和永久性房颤组37例;同时选取年龄和性别相匹配的30名健康志愿者作为对照组。采用酶联免疫吸附法测定所有研究对象的血清白细胞介素-18和白细胞介素-6水平,并用超声心动图测定其左心房内径。结果:永久性房颤组血清白细胞介素-18和白细胞介素-6水平均高于持续性房颤组,持续性房颤组血清白细胞介素-18和白细胞介素-6水平均高于阵发性房颤组,阵发性房颤组血清白细胞介素-18和白细胞介素-6水平均高于对照组,差异均有统计学意义,P<0.05;房颤患者左心房内径均大于对照组,永久性房颤组左心房内径大于持续性房颤组,持续性房颤组左心房内径大于阵发性房颤组,差异均有统计学意义,P<0.05。白细胞介素-18水平与左心房内径成正相关r=0.26,P<0.01;白细胞介素-6水平与左心房内径成正相关r=0.31,P<0.01;白细胞介素-18与白细胞介素-6水平成正相关,r=0.34,P<0.01。结论:房颤患者的白细胞介素-6和白细胞介素-18水平升高,左心房内径增大;白细胞介素-6和白细胞介素-18在心房颤动的发病机制中可能具有重要的作用。

Objective:To study the relationship between Interleukin-6,Interleukin-18 and atrial fibrillation.Methods:From December 2017 to December 2018,71 patients with atrial fibrillation admitted by emergency department and cardiovascular department in our hospital were divided into paroxysmal atrial fibrillation group with 11 cases,persistent atrial fibrillation group with 23 cases and permanent atrial fibrillation group with 37 cases according to the duration of atrial fibrillation.Meanwhile,30 healthy volunteers matched by age and sex were selected as the control group.The levels of serum interleukin-18 and interleukin-6 were measured by enzyme-linked immunosorbent assay,and left atrial diameter was measured by echocardiography.Results:The levels serum interleukin-18 and interleukin-6 in permanent atrial fibrillation group were higher than those in persistent atrial fibrillation group,the levels of serum interleukin-18 and interleukin-6 in persistent atrial fibrillation group were higher than those in paroxysmal atrial fibrillation group,the levels of serum interleukin-18 and interleukin-6 in paroxysmal atrial fibrillation group were higher than those in control group,all differences were statistically significant,P<0.05.The left atrial diameters of patients in atrial fibrillation were larger than that of control group,the left atrial diameters of patients in permanent atrial fibrillation were larger than that of patients in persistent atrial fibrillation,and the left atrial diameters of patients in persistent atrial fibrillation was larger than that of patients in paroxysmal atrial fibrillation,all differences were statistically significant,P<0.05.The level of interleukin-18 was positively correlated with the left atrial diameter,r=0.26,P<0.01;the level of interleukin 6 was positively correlated with the left atrial diameter,r=0.31,P<0.01;and the level of interleukin-18 was positively correlated with the level of interleukin-6,r=0.34,P<0.01.Conclusion:The levels of interleukin-6 and interleukin-18 increased in patients with atrial fibrillation,and their left atrial diameters also increased.Interleukin-6 and interleukin-18 may play an important role in the pathogenesis of atrial fibrillation.