非甾体类抗炎药在幼儿髋部矫形术后疼痛治疗中的效价分析

Analysis of the potency of non-steroidal anti-inflammatory drugs in the treatment of pain in children after hip orthopedic surgery

目的:比较常用的非甾体类抗炎药在幼儿髋部矫形术后疼痛治疗中的有效性、安全性和经济性。方法:选取2016年9月—2018年8月收治的小儿骨科髋关节脱位或半脱位并择期行手术治疗的1~3岁患儿90例,随机分为三组,每组30例,A组为酮咯酸氨丁三醇注射液组(静脉给药),B组为布洛芬混悬液组(口服给药),C组为对乙酰氨基酚栓组(直肠给药)。分析三种不同给药途径药物的镇痛效果、起效时间、显效时间、不良反应及药物成本。结果:在疼痛缓解有效率方面,三组比较,差异无统计学意义(P>0.05)。在疼痛得到缓解的起效时间和显效时间方面,静脉给药能快速且有效缓解疼痛,效果明显优于口服给药和直肠给药,A组与B组和C组比较,差异有统计学意义(P<0.05)。在不良反应方面,C组发生率最低,三组比较,差异有统计学意义(P<0.05)。C组用药经济学最小成本明显低于A、B两组,差异有统计学意义(P<0.05)。A组的起效时间和显效时间最短,C组的不良反应最少也最经济。结论:1~3岁幼儿髋部矫形术后镇痛首选对乙酰氨基酚栓,此药物给药方式易于操作、剂量吸收准确、不良反应少、成本低,同时效果显著。

Objective:To compare the efficacy,safety and economy of commonly used non-steroidal anti-inflammatory drugs in the treatment of postoperative hip orthopedic pain.Methods:Ninety-six children aged 1 to 3 years with pediatric orthopedics who underwent hip dislocation or subluxation and who underwent elective surgery from September 2016 to August 2018 were randomly divided into three groups.Group A was ketorolac tromethamine.injection group(intravenous administration),group B was ibuprofen suspension group(oral administration),group C was acetaminophen suppository group(rectal administration),30 cases in each group.The analgesic effect,onset time,marked effect time,adverse reaction and drug cost of drugs with different routes of administration Were analyzed of 3 modes of adminiseration.Results:In terms of the effectiveness of pain relief,there was no significant difference between the three groups(P>0.05).In terms of the onset time and effective time of pain relief,intravenous administration can quickly and effectively relieve pain,and the effect is significantly better than the oral administration group and the rectal administration group.The difference between the A group and the B group and the C group is statistically different.Learning meaning.In terms of adverse reactions,the incidence of group C was the lowest,and the difference between the three groups was statistically significant(P<0.05).The minimum cost of drug use in group C was significantly lower than that in group A and B,and the difference was statistically significant(P<0.05).The onset time and markedly effective time of group A were the shortest,and the adverse reactions of group C were the least and most economical.Conclusion:The acetaminophen suppository is the first choice for postoperative analgesia after hip orthopedic surgery in children aged 1~3 years.The drug is easy to handle,accurate in dose absorption,less adverse reaction,low cost and significant effect.