海绵抗肿瘤活性成分研究进展

Recent progress in anti-tumor active metabolites from sponges

海绵在其长期进化过程中形成了特殊的代谢过程,产生了许多结构新颖和生物活性显著的次级代谢产物,这些次级代谢产物已成为开发海洋药物或先导化合物的重要来源。本文主要从近几年来研究者对海洋不同海绵属来源的生物碱类、萜类、大环内酯类等化合物进行综述,介绍了其化学结构和抗肿瘤活性,为海洋天然产物的开发提供一定参考。

Sponges have established special metabolic processes to adapt the ocean environment during the long evolvement.Many secondary metabolites have been generated from sponges with novel structures and various potent biological activities,which can be used in the development of marine drugs and lead compounds.In this review,we mainly summarized the chemical structure and antitumor activity of alkaloids,terpenoids,macrolides and other compounds from the sponges.The review aims to provide useful information for developing marine natural products.