奥拉西坦与吡拉西坦的药理分析及临床效果

Pharmacological Analysis and Clinical Effect of Oracetam and Piracetam

目的分析对脑梗死患者实施奥拉西坦与吡拉西坦治疗的效果以及相关药理分析,以此为临床提供相关指导。方法采用奇偶法将2017年10月至2018年10月我院96例脑梗死患者分为对照组(48例,应用吡拉西坦治疗)、试验组(48例,给予奥拉西坦治疗)。比较两组患者不良反应发生情况、认知功能改善情况、生活质量评分。结果比较两组患者不良反应发生情况,试验组不良反应总发生率5例(10.42%)例低于对照组发生率7例(14.58%)例,但组间对比无统计学意义P>0.05;对比两组患者生活质量以及认知功能变化情况,试验组认知功能评分与生活质量评分均高于对照组,组间对比存在明显差异P<0.05。结论临床对奥拉西坦与吡拉西坦的临床治疗效果进行简要分析,其奥拉西坦可全面改善患者认知功能,改善其生活质量,其临床不良反应发生率较低,用药安全系数较高。

Objective To analyze the effect of oracetam and piracetam in the treatment of cerebral infarction patients and the relevant pharmacological analysis,so as to provide relevant guidance for clinical practice.Methods From October 2017 to October 2018,96 patients with cerebral infarction in our hospital were divided into control group(48 patients were treated with piracetam)and experimental group(48 patients were treated with oracetam)by parity method.Adverse reactions,cognitive function improvement and quality of life scores were compared between the two groups.Results The incidence of adverse reactions in the two groups was compared.The total incidence of adverse reactions in the experimental group was 5 cases(10.42%),lower than that in the control group 7 cases(14.58%).After comparing the changes in quality of life and cognitive function between the two groups,the scores of cognitive function and quality of life in the experimental group were both higher than those in the control group,and there was a significant difference between the two groups(P<0.05).Conclusion The clinical treatment effect of oracetam and piracetam was briefly analyzed.Oracetam can comprehensively improve the cognitive function and the quality of life of patients,with a low incidence of clinical adverse reactions and a high drug safety coefficient.