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培美曲塞序贯吉非替尼用于吉非替尼耐药肺腺癌的疗效观察 被引量:1

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摘要 目的探讨培美曲塞序贯吉非替尼用于吉非替尼耐药的肺腺癌的临床疗效。方法采用培美曲塞序贯吉非替尼方案对80例吉非替尼耐药的肺腺癌患者进行治疗,观察近期疗效和化疗不良反应,随访至2018年1月。结果80例患者部分缓解58例(72.5%),稳定20例(25.0%),进展2例(2.5%),有效率为92.5%。中位生存时间为25.8个月。发生腹泻33例(66.0%)、白细胞降低25例(50.0%)、肝功损害20例(40.0%)、贫血15例(30.0%)、血小板下降15例(30.0%)。结论对于吉非替尼耐药的肺腺癌患者采用培美曲塞序贯吉非替尼方案进行治疗是一个不错的选择,有效率较高。
作者 姜俊昌
出处 《中国医药指南》 2019年第21期66-66,共1页 Guide of China Medicine
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  • 1Cappuzzo F,Hirsch FR,Rossi E,et al.Epidermal growth factor receptor gene and protein and Gefitinib sensitivity in non-small-cell lung cancer[J].J Natl Cancer Inst,2005,97(9):643-655.
  • 2Hirsch FR,Varella-Garcia M,McCoy J,et al.Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to Gefitinib in patients with bronchioloalveolar carcinoma subtypes:A southwest oncology group study[J].J Clin Oncol,2005,23(28):6838-6845.
  • 3Hirsch FR,Varella-Garcia M,Bunn Jr PA,et al.Molecular predictors of outcome with Gefitinib in a phase Ⅲ placebo-controlled study in advanced non-small-cell lung cancer[J].J Clin Oncol,2006,24(31):5034-5042.
  • 4Lynch TJ,Bell DW,Sordella R,et al.Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to Gefitinib[J].N Engl J Med,2004,350(21):2129-2139.
  • 5Paez JG,Ja nne PA,Lee JC,et al.EGFR mutations in lung cancer:Correlation with clinical response to Gefitinib therapy[J].Science,2004,304(5676):1497-1500.
  • 6Sequist LV,Joshi VA,Janne PA,et al.Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing[J].Oncologist,2007,12(1):90-98.
  • 7Sequist LV,Bell DW,Lynch TJ,et al.Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer[J].J Clin Oncol,2007,25 (5):587-595.
  • 8Tsao MS,Sakurada A,Cutz JC,et al.Erlotinib in lung cancer:Molecular and clinical predictors of outcome[J].N Engl J Med,2005,353(2):133-144.
  • 9Mok T,Wu YL,Thongprasert S,et al.Gefitinib or Carboplatin-Paclitaxel in pulmonary adenocarcinoma[J].N Engl J Med,2009,361(10):947-957.
  • 10Maemondo M,Inoue A,Kobayashi K,et al.Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR[J].N Engl J Med,2010,362(25):2380-2388.

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