期刊文献+

地特胰岛素联合瑞格列奈治疗老年2型糖尿病的临床效果评价 被引量:2

下载PDF
导出
摘要 目的分析地特胰岛素联合瑞格列奈治疗老年2型糖尿病的临床效果。方法择取某院就诊的老年2型糖尿病患者98例,时间在2016年4月20日至2018年2月22日,通过随机颜色球抽取的方法将其分为两组。分别进行地特胰岛素、地特胰岛素联合瑞格列奈治疗,对比两组血糖水平改善情况、治疗情况、不良反应发生情况。结果观察组空腹血糖为(6.79±0.57)mmol/L、餐后2 h血糖为(8.24±1.11)mmol/L、糖化血红蛋白为(6.61±0.33)%、血糖恢复时间为(4.52±1.11)d、胰岛素使用量为(15.36±3.54)U、不良反应发生例数有2例,上述数据与对照组数据之间进行比较,存在较大差异性,P<0.05。结论地特胰岛素联合瑞格列奈治疗老年2型糖尿病效果显著,可推广。
作者 富琳娜
机构地区 本溪市金山医院
出处 《中国医药指南》 2019年第21期138-139,共2页 Guide of China Medicine
  • 相关文献

参考文献11

二级参考文献76

  • 1俞璐,罗敏.氧化应激与糖尿病血管并发症[J].国外医学(内分泌学分册),2005,25(6):396-398. 被引量:16
  • 2Philis-Tsimikas A, Charpentier G, Clauson P, et al. Comparison of once daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes. Clin Ther, 2006, 28:1569-1581.
  • 3Hermansen K, Davies M, Derezinski T, et al. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care, 2006, 29:1269-1274.
  • 4Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006, 295..1681-1687.
  • 5Hennige AM, Sartorius T, Tschritter O, et al. Tissue selectivity of insulin detemir action in vivo. Diabetologia, 2006, 49: 1274-1282.
  • 6Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes[ J ] . JAMA, 2006, 295 (14) : 1681-1687.
  • 7Monnier L,Colette C,Owens DR. Integrating glycaemic variability in the glyeaemic disorders of type 2 diabetes : a move towards a unified glucose tetrad concept[ J ] . Diabetes Metabolism Research and Reviews, 2009, 25 (5) : 393-402.
  • 8Piconi L, Quagliaro L, Da Ros R, et al. Intermittent high glucose en- hances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture : the role of poly ( ADP-ri- bose ) polymerase [ J ]. Thromb Haemost,2004,2 ( 8 ) : 1453-1459.
  • 9Quagliaro L, Piconi L, Assaloni R, et al. Intermitenthigh glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells : therole of protein kinase C and NAD (P) H-oxidase activation [ J ] . Diabetes ,2003 ,52 ( 11 ) : 2795-2804.
  • 10Cryer PE, Davis SN, Shamoon H. Hypoglycemia in diabetes. Diabetes Care, 2003, 26:1902-1912.

共引文献160

同被引文献29

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部