门静脉压力变化对肝再生影响的研究进展

Research progress about the effect of portal vein pressure on liver regeneration

小肝综合征和肝功能衰竭仍是小体积肝移植或扩大肝切除术后的严重并发症。因此,研究术后肝再生的机制并且探索有效途径来促进肝再生至关重要。大量研究均证实,在肝切除或肝移植术后,门静脉压力的改变可能是启动和维持肝再生进程,甚至是终止肝再生的必要因素。本文就近年来术后门静脉压力变化对肝再生影响的研究进展进行综述。

The occurrence of small liver syndrome and liver failure is still a serious complication that threatens the survival of patients after small liver transplantation or extended liver resection.Therefore,it is very important to understandthe mechanism of liver regeneration after operation and look for effective ways to promote liver regeneration.Many experiments have confirmed that changes in portal venous pressure(PVP)may be necessary to initiate and maintain liver regeneration processes and even terminate liver regeneration.This article reviews the recent research progress about the effect of PVP on liver regeneration.