摘要
In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes,and further oxidative aromatization and oxidation to complete the total syntheses.
In this paper, we report the concise total syntheses of three botryane sesquiterpenoids: dehydrobotrydienal, dehydrobotrydienol, and 10-oxodehydrodihydrobotrydial. The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes, and further oxidative aromatization and oxidation to complete the total syntheses.
基金
supported by the National Natural Science Foundation of China (Nos. 21772008, 21632002 and U1606403)
Natural Science Foundation of Guangdong Province (No. 2016A030306011)
Shenzhen Basic Research Program (Nos. JCYJ20170818090044432 and JCYJ20160226105337556)
Qingdao National Laboratory for Marine Science and Technology (No. LMDBKF201703)
