摘要
α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction(nitroaldol condensation)with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes.As such,a variety of optically activeβ-nitro-substituted tertiary alcohols bearing alkyne moieties were obtained in good to excellent yields(42%–99%)and moderate to good level of enantiomeric excess(up to 87%ee).
α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction(nitroaldol condensation)with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes. As such, a variety of optically active β-nitro-substituted tertiary alcohols bearing alkyne moieties were obtained in good to excellent yields(42%–99%) and moderate to good level of enantiomeric excess(up to 87% ee).
基金
supported by grants from National Key Program (No. 2016YFA0200302, Study on application and preparation of aroma nanocomposites)
National Natural Science Foundation of China (NSFC, No. 21472213)
Croucher Foundation (Hong Kong) in the form of a CAS-Croucher Foundation Joint Laboratory Grant
