摘要
Previous studies suggest that air pollution has a negative effect on semen quality.However,most studies are cross-sectional and the results are controversial.This study investigated the associations between air pollutants(PM25,PM10,SO2,NO2,CO,and O3)and seme n quality among sperm donation candidates,especially when the air pollution was artificially con trolled in Beijing,China.We an a lyzed 8945 semen samples in the human sperm bank of Peki ng Un iversity Third Hospital(Beijing,China)from October 2015 to May 2018.Air pollution data during the entire period(0-90 days prior)and key stages(0-9,10-14,and 70-90 days prior)of sperm development were collected from the China National Environmental Monitoring Centre.The association between air pollutants and seme n parameters(sperm con centrati on and progressive motility)was an a lyzed by a mixed model adjusted for age,abstinence duration,month,and average ambient temperature.Only O3 during key stages of 0-9 days and 10-14 days and the entire period was negatively associated with sperm concentration between 2015 and 2018(P v 0.01).During the period of air pollution control from November 2017 to January 2018,except for the in crease in O3 concentration,other five pollutants'concentrations decreased compared to those in previous years.In this period,the sperm concentration decreased(P<0.001).During the pollution-control period,O3 exposure 10-14 days prior was negatively associated with sperm concentration(95%Cl:-0.399—0.111;P<0.001).No significant association was found between the other five pollutants and semen quality during that period?Our study suggested that only O3 exposure was harmful to semen quality.Therefore,O3 should not be neglected during pollution control operation.
基金
This research was supported by the Key Program of National Natural Science Foundation of China(Grant No.81630087 and 81601272)
the National Key Research and Development Program of China(Grant No.2017YFC1002001).All these sponsors had no role in the study design,in the collection,analysis,and interpretation of data,in the writing of the report,or in the decision to submit the article for publication.
