白细胞分化抗原147、血管内皮生长因子蛋白表达与肺腺癌患者临床分期、淋巴结转移的关系

Relationship between leukocyte differentiation antigen 147, vascular endothelial growth factor protein expression and clinical stage, lymph node metastasis in patients with lung adenocarcinoma

目的探讨白细胞分化抗原147(CD147)、血管内皮生长因子(VEGF)蛋白表达与肺腺癌患者的临床分期、淋巴结转移的关系。方法选取昆明医科大学第三附属医院2015年10月~2018年10月肺腺癌患者78例,取其肺腺癌组织与相应癌旁正常肺组织标本,以免疫组织化学SP法检测患者肺腺癌组织和相应癌旁正常肺组织标本中CD147、VEGF蛋白表达,并分析CD147、VEGF蛋白表达和患者淋巴结转移、临床分期之间关系。结果肺腺癌组织中CD147、VEGF蛋白阳性表达率均高于癌旁正常肺组织,差异有统计学意义(P<0.05);有淋巴结转移、临床分期Ⅲ~Ⅳ期患者的肺腺癌组织中CD147、VEGF蛋白阳性表达率均高于无淋巴结转移及临床分期Ⅰ~Ⅱ期患者,差异均有统计学意义(均P<0.05)。结论肺腺癌组织中CD147、VEGF蛋白均呈高表达,且两者表达水平与淋巴结转移、临床分期相关,可将其作为肺腺癌诊断、恶性程度评估的重要指标。

Objective To investigate the relationship between the expression of leukocyte differentiation antigen 147(CD147)and vascular endothelial growth factor(VEGF)protein and clinical stage,lymph node metastasis in patients with lung adenocarcinoma.Methods A total of 78 patients with lung adenocarcinoma from October 2015 to October 2018 in the Third Affiliated Hospital of Kunming Medical University were enrolled.The lung adenocarcinoma tissues and corresponding normal lung tissues were taken and the lung glands were detected by immunohistochemical SP method.The expressions of CD147 and VEGF protein in cancer tissues and corresponding normal lung tissues were analyzed,and the relationship between CD147,VEGF protein expression and lymph node metastasis and clinical stage was analyzed.Results The positive expression rates of CD147 and VEGF protein in lung adenocarcinoma tissues were higher than those in corresponding normal lung tissues,the differences were statistically significant(P<0.05).The positive expression rates of CD147 and VEGF protein in lung adenocarcinoma tissues with lymph node metastasis and clinical stageⅢ-Ⅳwere higher than those in non-lymph node metastasis and clinical stageⅠ-Ⅱpatients,the differences were statistically significant(all P<0.05).Conclusion The expressions of CD147 and VEGF in lung adenocarcinoma are highly expressed,and their expression levels are related to lymph node metastasis and clinical stage.They can be used as an important index for the diagnosis and malignant degree evaluation of lung adenocarcinoma.