人参合桃红四物汤对冠心病心绞痛患者心功能及血脂的影响

Effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris

目的探讨人参合桃红四物汤对冠心病心绞痛患者心功能及血脂的影响。方法选择2015年9月~2018年6月广东省第二中医院白云院区收治的冠心病心绞痛患者101例,根据随机数字表法将患者分为对照组(50例)和研究组(51例)。对照组给予常规综合治疗,研究组在对照组的基础上联合人参合桃红四物汤治疗。比较两组患者临床疗效、心功能指标、血脂指标变化情况,观察两组患者治疗期间不良反应发生情况。结果研究组治疗后临床总有效率为94.12%,显著高于对照组(74.00%),差异有统计学意义(P<0.05)。研究组治疗后左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)显著低于对照组,左心室射血分数(LVEF)显著高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后LVESD、LVEDD明显降低,LVEF明显升高,差异有统计学意义(P<0.05)。研究组患者治疗后三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)显著低于对照组,高密度脂蛋白胆固醇(HDL-C)显著高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,两组TG、TC、LDL-C明显降低,HDL-C明显升高,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生情况比较差异无统计学意义(P>0.05)。结论人参合桃红四物汤治疗冠心病心绞痛患者效果确切,可有效改善患者心功能以及血脂情况,且不增加不良反应发生率,具有一定的临床应用价值。

Objective To investigate the effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris.Methods One hundred and one patients with coronary heart disease and angina pectoris admitted to Baiyun Branch of Guangdong Second Hospital of Traditional Chinese Medicine from September 2015 to June 2018 were selected.The patients were divided into control group(50 cases)and study group(51 cases)according to the random number table method.The control group was treated with routine comprehensive treatment,while the study group was treated with Ginseng combined with Taohong Siwu Decoction on the basiss of the control group.The changes of clinical efficacy,cardiac function index and blood lipid index were compared between the two groups,and the adverse reactions during treatment were observed.Results The total effective rate of the study group was 94.12%after treatment,which was significantly higher than that in the control group(74.00%),and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)of the study group were significantly lower than that of the control group,and the left ventricular ejection fraction(LVEF)was significantly higher than that of the control group,and the differences were statistically significant(P<0.05).Compared with before treatment,LVESD and LVEDD were significantly decreased and LVEF was significantly increased in the two groups after treatment,and the differences were statistically significant(P<0.05).After treatment,the triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)in the study group were lower than those in the control group,and high density lipoprotein cholesterol(HDL-C)was significantly higher than that in the control group,the differences were statistically significant(P<0.05).Compared with before treatment,TG,TC and LDL-C were significantly decreased in both groups,and HDL-C was significantly increased,the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups during treatment(P>0.05).Conclusion Ginseng combined with Taohong Siwu Decoction in the treatment of patients with coronary heart disease and angina pectoris has a definite curative effect,which can effectively improve the cardiac function and blood lipid status of patients without increasing the incidence of adverse reactions.It has certain clinical application value.