乳酸脱氢酶和C-反应蛋白在基层医院小儿重症支原体肺炎诊治中的应用

Application of LDH and CRP in the diagnosis and treatment of severe mycoplasmal pneumonia in children at primary hospitals

目的探讨乳酸脱氢酶(LDH)、C-反应蛋白(CRP)在基层医院小儿重症支原体肺炎诊的临床价值。方法选取2016年6月至2018年6月我院收治的的支原体肺炎患儿80例,依据病情程度分为轻症组和重症组各40例。所有患儿给予阿奇霉素10 mg/(kg.d),连续用药3天,停药4天后视病情继续给予阿奇霉素治疗,重症支原体肺炎组在常规治疗的基础上予以糖皮质激素治疗。比较轻症组与重症组治疗前后的LDH、CRP水平。结果重症组患儿治疗后LDH、CRP水平均较治疗前明显降低(P<0.05),且LDH、CRP水平明显高于轻症组(P<0.05)。结论LDH、CRP可作为基层医院小儿重症支原体肺炎诊治的有效指标,适用于基层医院。

Objective To investigate the clinical value of lactate dehydrogenase(LDH)and C-reactive protein(CRP)in the diagnosis of severe mycoplasmal pneumonia in children at primary hospitals.Methods In this study,80 children with mycoplasmal pneumonia in our hospital from June 2016 to June 2018 were selected.According to the severity of the disease,the sick children were divided into mild and severe groups,40 in each group.All sick children were treated with azithromycin 10 mg/(kg.d)and continuous medication for 3 days.Depending on the conditions,azithromycin might be continued after 4 days of withdrawal.Patients with severe mycoplasmal pneumonia were treated with glucocorticoids based on conventional treatment.The levels of LDH and CRP before and after treatment were compared between the two groups.Results Compared with before treatment,the LDH and CRP levels in the severe group were significantly reduced(P<0.05).The levels of LDH and CRP in the severe group were significantly higher than those in the mild group(P<0.05).Conclusion LDH and CRP can be used as effective indicators for the diagnosis and treatment of severe mycoplasmal pneumonia in children in primary hospitals.The two indexes are suitable for primary hospitals.