线虫在药物开发中的研究进展及在鉴别鹿茸活性成分上的应用

Progress in C. elegans Model Development for Drug Discovery, and Possible Application on Identification of Active Compounds of Velvet Antlers

秀丽隐杆线虫(Caenorhabditis elegans, C. elegans)是生命科学研究中的重要模式生物之一,由于其身体结构简单和寿命周期短暂等优势被用来研究整个生命过程不同阶段的分子调节机制,在药物开发领域也发挥了重要作用。因此本综述对秀丽隐杆线虫在药物开发方面的应用及研究进展进行了简要综述。鹿茸作为中国的传统名贵中药,在上千年里大多以粗提物的形式加以应用,鹿茸的具体活性成分及其相关药理作用一直有待于系统研究,由于线虫作为优秀的模式生物操作简单易于观察,可以较方便的对各成分进行效果鉴定,因此本综述对线虫在鉴别鹿茸活性成分中的潜在应用价值进行了探讨。

C. elegans is one of the most important model organisms in life science research C. elegans. Because of its simple body structure and short life cycle, it can be used to study the molecular regulation mechanism of the different stages of the whole life process. C. elegans has played an important role in drug development. Therefore,this review discussed the application and research progress of C. elegans in drug development as a brief summary.As a traditional Chinese precious medicine, deer velvet antlers have been used in the form of crude extracts in the past millennia. The specific active ingredients of deer antlers and its related pharmacological effects have yet to be systematically studied. Since C. elegans as the excellent model organisms are easy to be observed and operated,thus the effects of each component can be identified more readily. So in this review, we also discussed the potential application of C. elegans in the identification of active ingredients of deer velvet antlers.