细胞自噬在斑马鱼中的研究进展

Research Progress of Cell Autophagy in Zebrafish

细胞自噬是一种维持细胞内稳态的重要方式,并被发现与许多人类疾病相关。由于其具有重大的理论研究价值和潜在应用前景,是近年来生命科学领域的热点之一。细胞自噬的功能与机制在物种间是高度保守的,对它的研究已在多种模式生物中展开。斑马鱼是一种常用的脊椎模式动物,具有影像学、遗传学和发育生物学等学科研究的优势,也可用于高通量药物筛选,是研究细胞自噬的理想材料。目前在斑马鱼中展开的细胞自噬相关研究取得了很多进展。本研究首先简要地描述了自噬的发生过程,重点综述应用于斑马鱼中的自噬检测方法,以及利用斑马鱼模型进行的与自噬相关人类疾病的研究。

Autophagy is an important mechanism to maintain cellular homeostasis within cells, and has been linked to many human diseases. Due to its both great value in basic research and high potential in medical application,autophagy has become a hot field in life science in recent years. Cell autophagy is highly conserved both in functions and molecular mechanisms among species, and it has been reported in many model organisms. Zebrafish is a widely used vertebrate animal model, with advantages in imaging, genetics, developmental biology and high throughput drug screening, making this animal an ideal material for cell autophagy investigation. Much progress has been made in this field using zebrafish. Here we first introduce the occurrence process of autophagy, putting emphasis on the autophagy detection methods used in zebrafish and the studies of autophagy related human diseases using zebrafish.