心血管干细胞在心血管再生医学研究中的现状与展望

Current status and prospects of cardiovascular stem/progenitor cells in cardiovascular regenerative medicine

哈佛大学的Anversa等人被撤回30余项伪造研究的消息对心血管系统干细胞研究领域产生了令人沮丧的影响.通过骨髓细胞或成体心脏原位干/祖细胞分化再生心肌的理论已被否定.在过去的近20年中,众多医生、学者和机构花费大量精力和财力投入这项目前看似“无所收益”的研究中,但是心血管领域干细胞的研究成果是丰硕的,不能因为Anversa事件而全盘否定心血管干细胞研究领域的成就.本文回顾了心血管干细胞在这场风波中的进程始末,总结了目前心脏和血管干细胞的研究进展,并对其今后的研究方向进行展望,以重整和规划心血管干细胞和心血管再生医学领域正确的研究方向.

The retraction of more than 30 falsified studies by Anversa et al.from Harvard University has a frustrating impact on cardiovascular stem cell research.The theory of regenerating myocardium by differentiation of bone marrow cells or adult heart resident stem/progenitor cells has been denied while countless researchers have spent a lot of energy and financial resources on this seemingly“no income”research in the past 20 years.But the achievements of stem/progenitor cells in cardiovascular research are abundant,and should not be denied because of Anversa et al.This article reviews the controversy in the“Anversa events”,summarizes the current research progress of cardiac and vascular stem/progenitor cells,and prospects for future research directions.