细胞间黏附因子-1和内皮细胞特异性分子-1的表达在移植肾排斥反应中的临床意义

Pathological features of transplanted kidney rejection

目的探讨移植肾排斥反应的细胞间黏附因子-1(ICAM-1)与内皮细胞特异性分子-1(ESM-1)病理学特点。方法移植肾病人20例,根据移植肾术后排异情况分为正常组和排异组,每组各10例,记录不同肾组织的ICAM-1与ESM-1和肾功能变化情况。结果正常组术后移植肾功能持续改善直至恢复正常水平,排异组在出现排斥后出现移植肾功能下降,两组术后1天、3天、7天与1个月的肌酐比较差异有统计学意义(P<0.05)。正常组肾组织的ICAM-1与ESM-1表达阳性率分别为80.0%和90.0%,排异组分别为10.0%和10.0%,差异有统计学意义(P<0.05)。结论移植肾排斥反应比较常见,ICAM-1与ESM-1病理学表达阳性率与排斥反应程度相关,与肾功能有一定的相关性。

Objective To investigate the pathological features of intercellular adhesion molecule-1(ICAM-1)and endothelial cell specific molecule-1(ESM-1)in renal allograft rejection.Methods 20 patients who underwent renal transplantation in our hospital were selected and were divided into the normal group of 10 cases and rejection group of 10 cases accorded to the rejection of transplanted kidney.Recorded the pathological immunohistochemistry of ICAM-1 and ESM-1 in different renal tissues,and renal function changes were recorded.Results The renal function of the normal group continued to improve until the normal level was restored,the renal function of the rejection group were decreased after operation compared the difference of creatinine between the two groups at postoperative 1d,3d,7 d and 1months were statistically significant(P<0.05).The positive rates of ICAM-1 and ESM-1 expression in the normal group were 80.0%and 90.0%,respectively,and were 10.0%and 10.0%in the rejection group,respectively,compared the difference were statistically significant(P<0.05).Conclusion Transplanted renal rejection is common,the positive rate of pathological expression of ICAM-1 and ESM-1 are related to the degree of rejection,they also have certain correlation with renal function.