13C-尿素呼气试验在上消化道疾病检查中的临床价值

Clinical Value of 13C-urea Breath Test in Upper Digestive Tract Disease Examination

目的:分析^13C-尿素呼气试验(^13C-UBT)在有上消化道症状患者的临床应用价值。方法:50名患者被纳入研究。每个患者都接受了^13C-UBT检测,随后行胃镜检查和黏膜活检,以快速尿素酶试验(RUT)测定尿素酶活性。结果:14例(28%)患者UBT及RUT测定均呈阳性。4例(8%)UBT测定呈阳性,但RUT测定呈阴性,2例(4%)UBT测定呈阴性,但RUT测定呈阴性,其余30例(60%)在两项检测中均为阴性结果。结论:上消化道疾病幽门螺杆菌(Hp)感染检测方法中,^13C-UBT是一种高灵敏度和特异性的方法。^13C-UBT的阳性结果是Hp感染根除治疗的基础。

Objective:To analyze the^13C-urea breath test(^13C-UBT)in the upper digestive tract Clinical application value of symptomatic patients.Methods:50 patients were included in the study.Each patient underwent^13C-UBT testing followed by gastroscopy and mucosal biopsy to determine urease activity by rapid urease test(RUT).Results:Fourteen(28%)patients were positive for both UBT and RUT.4 cases(8%)were positive for UBT,but negative for RUT,2(4%)negative for UBT,but negative for RUT,and 30(60%)were negative for both tests..Conclusion:^13C-UBT is a highly sensitive and specific method for detecting Helicobacter pylori(Hp)infection in upper gastrointestinal diseases.The positive result of^13C-UBT is the basis of Hp infection eradication therapy.