布地奈德经鼻雾化吸入治疗慢性鼻咽炎的临床疗效和不良反应发生率

Clinical Efficacy of Budesonide in the Treatment of Chronic Nasopharyngitis by Nasal Nebulization

目的:探讨慢性鼻咽炎采用布地奈德经鼻雾化吸入治疗后的临床效果与不良反应发生率。方法:取2017年5月-2018年5月内本院收治的68例慢性鼻咽炎患者开展研究。用随机分组原则将68例患者分为对照组、观察组,对照组(34例)采用常规治疗,观察组(34例)采用布地奈德经鼻雾化吸入治疗,分析两组临床疗效、临床症状评分、血清炎性因子水平以及不良反应发生率。结果:临床疗效相比,观察组高于与对照组,有统计学意义(X^2=5.100,P=0.024);观察组临床症状评分、不良反应发生率均比对照组低,差异有统计学意义(t=20.050,16.839,24.846.23.789,20.364)(X2=5.397)(P=0.000,0.000,0.000,0.000,0.000,P=0.020);观察组血清炎性因子水平高于对照组,差异有统计学意义(t=7.642,11.419,5.635,6.135,P=0.000,0.000,0.000,0.000)。结论:慢性鼻咽炎患者应用布地奈德经鼻雾化吸入治疗,既可改善临床症状及血清炎性因子水平,又可降低不良反应、提高治疗效果,值得临床推广应用。

Objective:To investigate the clinical effects and adverse reactions of chronic nasopharyngitis after budesonide nasal inhalation.Methods:A total of 68 patients with chronic nasopharyngitis admitted to our hospital from May 2017 to May 1818 were enrolled in the study.68 patients were divided into control group and observation group by random grouping principle.The control group(34 cases)was treated with conventional therapy,and the observation group(34 cases)was treated with budesonide by nasal nebulization.The clinical efficacy and clinical analysis of the two groups were analyzed.Symptom score,serum inflammatory factor levels,and incidence of adverse reactions.Results:Compared with the control group,the clinical effect was statistically significant(X^2=5.100,P=0.024);The clinical symptom score and adverse reaction rate were observed in the observation group.The difference was statistically significant(t=20.050,16.839,24.846.23.789,20.364)(X^2=5.397)(P=0.000,0.000,0.000,0.000,0.000,P=0.020).The serum inflammatory factor level in the observation group was higher than that in the control group(t=7.642,11.419,5.635,6.135;P=0.000,0.000,0.000,0.000).Conclusion:The treatment of budesonide by nasal nebulization in patients with chronic nasopharyngitis can not only improve the clinical symptoms and serum inflammatory factor levels,but also reduce adverse reactions and improve the therapeutic effect.It is worthy of clinical application.