人参中活性组分与肠道菌群的互动调控研究进展

Update on the Bidirectional Regulations Between the Active Ingredients in Ginseng and the Gut Microbiota

人参为传统补益中药,具有免疫调节、抗疲劳、抗肿瘤等作用。近年来的研究表明,人参中活性组分与肠道菌群存在互动调控,可能是揭示其潜在作用机制的新途径。回顾了肠道菌群介导的人参皂苷及多糖组分的代谢,并从人参活性组分调节肠道微生物的角度探讨了其在防治溃疡性结肠炎、肥胖、2型糖尿病、缺血性脑中风等疾病中的机制。肠道菌群与中药组分相互作用研究的深入将会推动对人参药效机制的研究,为相关中药的创新研究及开发提供新思考。

Ginseng(Panax ginseng C.A.Mey)is a traditional tonic medicine with immunoregulatory,anti fatigue and anti tumor efficacy.Recent studies have shown a bidirectional regulation between active ingredients in ginseng and the gut microbiota,which may shed novel insights into its mechanisms of action.This review outlines the disposition of ginsenosides and ginseng polysaccharides by the gut microbiota,and,from the perspective of gut microbiota modulation,discusses the potential mechanism in the prevention or treatment of diseases including ulcerative colitis,obesity,type 2 diabetes and ischemic stroke.The progress on the crosstalk between gut microbiota and phytochemicals is expected to deepen the mechanistic understanding of ginseng pharmacology,as well as inspiring new thoughts in the research and development of traditional Chinese medicine.