双歧杆菌三联活菌胶囊联合奥曲肽治疗急性重症胰腺炎疗效研究

The effect of bifidobacterium triple live bacteria capsule combined with octreotide in the treatment of acute severe pancreatitis

目的探讨双歧杆菌三联活菌胶囊联合奥曲肽治疗急性重症胰腺炎的临床疗效。方法选取自2016年8月至2018年8月收治的120例急性重症胰腺炎患者,采用随机数字表法分为常规组(n=60)与观察组(n=60)。常规组患者给予奥曲肽,观察组患者在常规组治疗基础上给予双歧杆菌三联活菌胶囊。比较两组患者临床疗效,血清脂肪酶、血清淀粉酶、血清炎性因子[白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)]水平,临床症状缓解时间及不良反应发生情况。结果治疗后,观察组患者总有效率为95.0%(57/60),显著高于常规组的81.7%(49/60),差异有统计学意义(P<0.05)。治疗后,两组患者血清淀粉酶、血清脂肪酶水平均较治疗前降低,且观察组低于常规组,差异均有统计学意义(P<0.05)。治疗后,两组患者IL-6、CRP、TNF-α水平均较治疗前降低,且观察组低于常规组,差异有统计学意义(P<0.05)。治疗后,观察组患者腹水消失时间、腹痛消失时间、尿淀粉酶恢复时间、血淀粉酶恢复时间、排气恢复时间均显著短于常规组,差异有统计学意义(P<0.05)。结论双歧杆菌三联活菌胶囊联合奥曲肽治疗急性重症胰腺炎临床疗效较好,有助于降低血清淀粉酶、血清脂肪酶水平,改善血清炎性因子水平。

Objective To investigate the clinical effect of bifidobacterium triple live bacteria capsule combined with octreotide in the treatment of acute severe pancreatitis.Methods A retrospective study was performed on 120 cases of patients with acute severe pancreatitis who were admitted from August 2016 to August 2018.Patients were randomly divided into the conventional group(n=60)and the observation group(n=60).Patients in the conventional group were given octreotide,while patients in the observation group were given bifidobacterium triple live bacteria capsules on the basis of treatment in the conventional group.The clinical efficacy,serum lipase,serum amylase,serum inflammatory factor levels[interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),C-reactive protein(CRP)],clinical symptom remission time and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 95.0%(57/60),which was significantly higher than that of the conventional group(81.7%,49/60),and the difference was statistically significant(P<0.05).After treatment,serum amylase and serum lipase levels in both groups were lower than before treatment,and the observation group was lower than the conventional group(P<0.05).After treatment,the levels of IL-6,CRP and TNF-αin both groups were lower than before treatment,and the observation group was lower than the conventional group(P<0.05).After treatment,the time of ascites disappearance,abdominal pain disappearance,urine amylase recovery time,blood amylase recovery time and exhaust recovery time in the observation group were significantly shorter than those in the conventional group(P<0.05).Conclusion The clinical efficacy of bifidobacterium triple live bacteria capsule combined with octreotide in the treatment of acute severe pancreatitis is good,which is helpful to reduce serum amylase and serum lipase levels and improve serum inflammatory factor levels.