双相情感障碍发作期患者血清尿酸水平及其影响因素的研究

Serum uric acid level during attacks of bipolar disorder and its influencing factors

目的探讨双相情感障碍(BD)发作期患者血清尿酸(UA)水平及临床影响因素。方法纳入2017年12月至2019年1月山西大医院精神卫生科96例BD发作期住院患者,同时期同地区144名健康人群作为健康对照组,检测比较2组血清UA,总胆固醇(CHO),甘油三酯(TG)水平及体质量指数(BMI)。结果BD发作期患者UA水平和HUA发生率显著高于健康对照组(P<0.01),不同临床相BD发作期患者UA水平没有统计学意义。男性UA水平均高于女性(P<0.01)。患者组UA水平与BMI、TG呈正相关,与病程呈负相关(均P<0.05),健康对照组UA水平与BMI、TG、CHO呈正相关(均P<0.01)。结论BD发作期患者UA水平较高,但不同临床相间UA水平无差异,性别、病程、BMI、CHO、TG是其临床影响因素,但其与症状严重程度和年龄无关。

Objective To investigate the serum uric acid(UA)during the attacks of bipolar disorder(BD)and its clinical influencing factors.Methods Ninety-six patients during BD attacks hospitalized in the Department of Mental Health,Shanxi Dayi Hospital between December 2017 and January 2019 were included in the study.A contemporary cohort of 144 healthy subjects was included in the normal control group.The levels of serum UA,total cholesterol(CHO),triglyceride(TG)and body mass index(BMI)were compared between the two groups.Results The UA level and incidence of hyperuricemia(HUA)in patients during BD attacks were significantly higher than those in the normal control group(P<0.01).There was no statistically significant difference in the UA level between patients with different clinical phases of BD attacks.There was statistical significance in the UA level among patients with different genders,and the UA level in males was significantly higher than that in females(both P<0.01).The UA level in the patient group was positively correlated with BMI and TG,and negatively correlated with the course of disease(all P<0.05).The UA level in the normal control group was positively correlated with BMI,TG and CHO(all P<0.01).Conclusion Patients during BD attacks show high UA level,but there is no difference in UA level between different clinical phases.Gender,course of disease,BMI,CHO,and TG are the clinical influencing factors,but the severity of symptoms and age are not correlated with the UA level.