心脏磁共振评价化疗所致心肌损伤的研究进展

Cardiovascular Magnetic Resonance for Detection of Myocardial Impairments Caused by Chemotherapy

心脏磁共振是一种新型影像学诊断工具,除了可提供更加精准的形态学评估外,还可较为敏感地发现化疗期间心肌组织特征以及功能学的改变,作为评价肿瘤患者的心血管预后的手段。化疗早期心肌可表现为炎症水肿,及时干预可能有效逆转或减轻心肌毒性,随着化疗进程,部分心脏毒性较大的化疗药物可能导致不可逆的心脏结构及功能变化,并导致心肌细胞萎缩及间质纤维化。

Cardiac magnetic resonance is a new imaging tool that can provide a precise assessment of cardiac morphology.It can also sensitively detect myocardial tissue characteristics and functional changes during and after chemotherapy,and evaluate cardiovascular outcomes in cancer patients.In the early stage of chemotherapy,inflammation and edema may occurred on myocardium.Timely intervention could effectively reverse or reduce myocardial toxicity.However,with the progress of chemotherapy,some of the drugs with more severe cardiotoxicity may cause irreversible changes in cardiac structure and function and induce myocardial cell atrophy and interstitial fibrosis.