急性脑梗死患者血浆纤维蛋白原水平与预后的关系

Study on the relationship between plasma fibrinogen level and prognosis in patients with acute cerebral infarction

目的分析血浆纤维蛋白原水平对急性脑梗死患者预后的影响。方法选取急性脑梗死患者124例,依据入院24 h内血浆纤维蛋白原水平分为高水平组(>4 g/L)和正常水平组(≤4 g/L)。2组患者入院后均积极给予改善脑循环、保护脑细胞以及治疗脑水肿等措施。入院72 h后以Glasgow昏迷量表评估患者意识水平,以NIHSS量表评估患者神经功能缺损情况。发病3个月后,以临床神经功能缺损程度评分(NDS)判定治疗效果,以Barthel指数评估患者生活能力。结果高水平组患者入院72 h后Glasgow昏迷量表评分低于正常水平组,而NIHSS评分高于正常水平组,差异均有统计学意义(P<0.05)。发病3个月后,高水平组临床治疗效果及Barthel指数评分低于正常水平组,差异有统计学意义(P<0.05)。结论检测急性脑梗死患者血浆纤维蛋白原水平有助于判断病情及评估预后。

Objective To investigate the relationship between plasma fibrinogen level and prognosis in patients with acute cerebral infarction.Methods 124 cases of acute cerebral infarction patients were selected and divided into high level group(>4 g/L)and normal group(≤4 g/L)on the basis of plasma fibrinogen.After 72 hours of admission,the patients were assessed with Glasgow coma scale,evaluation of neurological deficits in patients with NIHSS scale.3 months after the onset,clinical neurological impairment score(NDS)to determine the effect of treatment,and take Barthel index to assess the living ability of the patients.Results High level group patients were admitted to the hospital for 72 hours after the Glasgow Coma Scale score was lower than the normal level group(P<0.05),and the NIHSS scale score was higher than the normal level group(P<0.05),the difference was statistically significant.After 3 months,the clinical treatment effect and Barthel index score of the high level group were lower than that of the normal level group(P<0.05),the difference was statistically significant.Conclusion Detection of plasma fibrinogen levels in patients with acute cerebral infarction is helpful to determine the severity of the disease,and to assess the prognosis of patients with acute cerebral infarction.