血管外膜炎症在动脉粥样硬化中的作用及研究进展

Role and research advances of vascular adventitial inflammation in atherosclerosis

血管外膜是动脉粥样硬化(atherosclerosis,AS)的积极参与者,其在AS发生、发展中的作用不容忽视。在AS病灶形成之前,血管外膜出现炎性细胞浸润、成纤维细胞增殖和迁移、血管滋养管增生等炎症反应,可能启动或加速AS的发生、发展。本文就近年来,血管外膜组织、细胞成分在AS形成过程中的变化及其对AS发生、发展的影响,以及基于外膜炎症的AS动物模型的研究进展做一综述。

Vascular adventitia is an active participant in atherosclerosis,and its role in the occurrence and development of atherosclerosis cannot be ignored.Prior to the formation of atherosclerotic lesions,inflammatory responses such as inflammatory cell infiltration,fibroblast proliferation and migration,and vasa vasorum proliferation appeared in the vascular adventitia,which may initiate or accelerate the occurrence and development of atherosclerosis.In this article,changes and effects of vascular tissue and cell components in the formation and development of atherosclerosis,as well as progress for atherosclerosis animal models based on adventitia inflammation,were reviewed.