卵巢上皮性癌组织中miR-338-3p的表达

Expression of miR-338-3p in epithelial ovarian cancer tissue

目的:检测微小RNA-338-3p(miR-338-3p)在卵巢上皮性癌组织中的表达情况,探讨其在卵巢癌发生发展中的作用。方法:采用qRT-PCR检测20例正常卵巢组织、20例良性卵巢上皮性肿瘤组织和65例卵巢上皮性癌组织中miR-338-3p的表达情况,分析卵巢上皮性癌与组织中miR-338-3p表达与临床病理指标的关系,Kaplan-Meier法分析miR-338-3p表达对卵巢癌患者生存的影响。结果:卵巢上皮性癌组织中miR-338-3p的表达显著低于正常卵巢组织和良性卵巢上皮性肿瘤组织(P<0.05)。临床分期晚、组织级别高、有淋巴结转移的卵巢上皮性癌组织中miR-338-3p表达低(P<0.05)。miR-338-3p表达水平相对较低的卵巢上皮性癌患者的总体生存率和无进展生存期明显短于miR-338-3p表达水平相对较高的患者(P<0.05)。结论:miR-338-3p低表达与卵巢癌患者预后不良有关,可作为卵巢癌预后的标记物。

Aim:To detect the expression of miR-338-3p in epithelial ovarian cancer tissue.Methods:The expressions of miR-338-3p in 20 specimens of normal ovary,20 specimens of benign epithelial ovarian tumor and 65 specimens of epithelial ovarian cancer tissues were detected by qRT-PCR,and its association with the clinicopathologic characteristics of epithelial ovarian cancer was analyzed.The relation between miR-338-3p expression and the survival of ovarian cancer patients was measured by Kaplan-Meier analysis.Results:The expression of miR-338-3p in epithelial ovarian cancer tissue was obviously lower than those in normal ovarian tissue and benign ovarian tumor(P<0.05).In epithelial ovarian cancer,lower expression of miR-338-3p was associated with more advanced FIGO stage,higher histological grade and lymph node metastasis(P<0.05).The overall survival rate and progression free survival rate of patients with lower miR-338-3p were obviously shorter(P<0.05).Conclusion:Low expression of miR-338-3p is related with poor prognosis of ovarian cancer patients,and miR-338-3p could be served as a biomarker for the prognosis of ovarian cancer.