生长激素在高龄卵巢储备功能减退者微刺激方案中的应用

Application of growth hormone in older patients with mild-stimulus protocol

目的探讨生长激素(growh hormone,GH)在高龄卵巢储备功能减退者微刺激方案促排卵中的应用疗效。方法回顾性分析180例进行体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)助孕的高龄卵巢储备功能减退者的临床资料,均采用微刺激方案,按是否添加GH分为研究组(添加GH)90例和对照组(不添加GH)90例。分析比较2组一般情况、IVF相关指标及助孕结局。结果①2组年龄、不孕年限、基础内分泌水平差异均无统计学意义(P>0.05)。②2组促性腺激素(gonadotropin,Gn)总量、Gn使用天数、人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)日雌激素水平、HCG日子宫内膜厚度、移植数、周期取消率差异均无统计学意义(P>0.05)。③研究组获卵数、受精率、卵裂率、优胚数均明显多于或高于对照组(P<0.05)。④研究组妊娠率稍高于对照组,但差异无统计学意义(P>0.05)。结论高龄者应用微刺激方案促排卵时,Gn同时添加GH可以增加获卵数、受精率、卵裂率,改善胚胎质量,有助于提高临床妊娠率。

Objective To investigate the therapeutic effect of growth hormone(GH)on ovulation induction in elderly patients with micro-stimulation.Methods A retrospective analysis of 180 patients with in vitro fertilization and embryo transfer(IVF-ET),all using micro-stimulation,according to whether GH was added or not,90 cases were divided into study group(GH added)and control group(GH not added)90 cases.Analyze and compare the general situation of the two groups,IVF related indicators and assisted pregnancy outcomes.Results①There was no significant difference in the age,infertility years and basal endocrine levels between two groups(P>0.05).②There were no significant differences in total gonadotropin,days of Gn use,estrogen level on human chorionic gonadotropin(HCG)day,endometrial thickness on HCG day,transplantation number and cycle cancellation rate between two groups(P>0.05).③The number of eggs harvested,fertilization rate,cleavage rateand number of high-quality embryos in the study group were significantly higher than those in the control group(P<0.05).④The pregnancy rate in the study group was slightly higher than that in the control group,but there was no significant difference(P>0.05).Conclusion GH can increase the number of eggs harvested and fertilization rate,cleavage rate,improve the quality of embryos and help to improve the clinical pregnancy rate when microstimulus is used in elderly patients.