孕中期唐氏筛查与产前诊断对预防出生缺陷的临床应用价值

Clinical value of Down’s screening and prenatal diagnosis in the second trimester to prevent birth defects

目的研究针对孕中期孕妇采用唐氏筛查和产前诊断对预防出生缺陷的临床应用价值。方法选择本院2016年6月至2018年6月接诊的430例孕妇进行唐氏筛查和产前诊断。抽取空腹静脉血进行血清分离,采用化学发光仪对AFP、HCG、uE3检测。将数据和孕妇综合情况输入分析软件中进行风险评估。另外对高危孕妇行羊水穿刺,观察诊断结果。结果对430例孕妇进行唐氏筛查,其中21-三体征高风险为1.86%,18-三体征高风险为1.16%,神经管缺陷高风险为0.7%,唐氏筛查不良率为3.72%。结论对孕中期孕妇采取唐氏筛查和产前诊断,能有效筛查出不良胎儿,较好的预防胎儿出生缺陷,提高了优生优育及人口素质,值得临床广泛应用。

Objective To study the clinical value of Down's screening and prenatal diagnosis in preventing birth defects for pregnant women in the second trimester of pregnancy.Methods 430 pregnant women in our hospital from June 2016 to June 2018 were screened and diagnosed before delivery.Fasting venous blood was extracted and serum was separated.AFP,HCG and uE3 were detected by chemiluminescence.The data and the comprehensive situation of pregnant women were input into the analysis software for risk assessment.In addition,high risk pregnant women underwent amniocentesis to observe the diagnosis results.Results 430 pregnant women were screened for Down's disease.The high risk of trisomy 21 was 1.86%,trisomy 18 was 1.16%,neural tube defect was 0.7%,and Down's disease rate was 3.72%.Conclusion Down's screening and prenatal diagnosis for pregnant women in the second trimester can effectively screen out unhealthy fetuses,better prevent fetal birth defects,improve eugenic and fertility and population quality,which is worthy of wide clinical application.