低分子肝素钠联合低剂量黄体酮治疗先兆流产的临床效果

Clinical effect of low molecular weight heparin combined with low dose progesterone in treatment of threatened abortion

目的探究先兆流产采用低分子肝素钠与低剂量黄体酮治疗的效果。方法选取本院2016年12月至2017年12月期间收治的先兆流产患者80例,采用数字随机表法将该80例患者分为实验组和参照组,各40例。参照组患者给予常规剂量的黄体酮治疗,实验组患者给予低分子肝素钠与低剂量的黄体酮联合治疗。比较两组患者临床症状缓解时间、不良反应发生情况。结果比较实验组与参照组患者不良反应发生情况,实验组总发生率5%低于参照组患者25%,组间对比差异有统计学意义(P<0.05);比较实验组与参照组患者临床症状缓解时间,实验组患者腰酸、止血、腹痛缓解时间等均短于参照组患者,组间对比差异有统计学意义(P<0.05)。结论治疗先兆流产采用低分子肝素钠与低剂量的黄体酮联合治疗,其临床效果显著,可全面改善患者临床症状,患者临床症状缓解时间均相对较短,并且其不良反应发生率也相对较少,临床用药安全性较低,值得临床推广运用。

Objective To investigate the effect of low molecular weight heparin sodium and low dose progesterone in threatened abortion.Methods Eighty patients with abortion who were admitted to our hospital from December 2016 to December 2017 were enrolled.The 80 patients were divided into the experimental group and the reference group by digital random table method,with 40 cases in each group.Patients in the reference group were treated with conventional doses of progesterone,and patients in the experimental group were given low-molecular-weight heparin sodium in combination with low-dose progesterone.The clinical symptom relief time and adverse reactions were compared between the two groups.Results The adverse reactions of the patients in the experimental group and the reference group were compared.The total incidence rate of the experimental group was 5%lower than that of the reference group.The statistical significance of the group was statistically significant(P<0.05).The patients in the experimental group and the reference group were compared.At the time of symptom relief,the patients in the experimental group were less likely to have backache,hemostasis,and abdominal pain relief time than the reference group.The difference between the groups was significant(P<0.05).Conclusion The treatment of threatened abortion with low molecular weight heparin sodium combined with low dose of progesterone has a clinical effect,which can improve the clinical symptoms of patients comprehensively.The clinical symptom relief time is relatively short,and the incidence of adverse reactions is relatively high.Less,the safety of clinical medication is low,and this combination of treatments can be widely applied.