依达拉奉用于治疗急性脑梗死的临床药理分析

Clinical pharmacological analysis of Edaravone in the treatment of Acute cerebral infarction

目的分析依达拉奉用于治疗急性脑梗死的临床药理。方法选取2017年6月至2018年6月期间广东省第二人民医院与广州市增城区人民医院收治的150例急性脑梗死患者,按照不同治疗方法将其分为对照组和观察组,各75例。对照组患者给予常规神经内科药物进行治疗,观察组患者在对照组用药基础上给予依达拉奉,观察两组患者临床疗效、治疗前后神经功能评分、生活能力评分、内皮素1(ET-1)及白细胞介素6(IL-6)。结果观察组临床总有效率为96%,对照组临床总有效率为76%,观察组明显更高,差异具有统计学意义(P<0.05);治疗前,两组患者神经功能评分、生活能力评分、ET-1及IL-6比较差异无统计学意义,治疗后,观察组神经功能评分、生活能力评分、ET-1及IL-6明显优于治疗前及对照组,差异具有统计学意义(P<0.05)。结论依达拉奉用于治疗急性脑梗死临床效果理想,其主要与依达拉奉能避免内皮细胞损伤,改善患者神经功能和炎性反应,减少梗死区白细胞浸润有关。

Objective To analyze the clinical pharmacology of Edaravone in the treatment of acute cerebral infarction.Methods 150 cases of acute cerebral infarction patients who were admitted to Guangdong second people's Hospital and Guangzhou Zengcheng District people's Hospital from June 2017 to June 2018,according to different treatment methods divided into the control group and the observation group,with 75 cases in each group.The control group were treated with routine neurology drugs,the observation group were treated with edaravone on the basis of the control group.The clinical effect,neurological function score and living ability score of the two groups were observed.Endothelin 1(ET-1)and White White Interferon 6(IL-6)before and after treatment of the two groupswere compared.Results The total clinical effective rate in the observation group was 96%,the total clinical effective rate in the control group was 76%,the observation group was significantly higher,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in neurological function score,living ability score,ET-1 and IL-6 of the two groups.After treatment,the neurological function score,living ability score,ET-1 and IL-6 in the observation group were significantly better than before treatment and the control group,the difference was statistically significant(P<0.05).Conclusion Edaravone is effective in the treatment of acute cerebral infarction,it's mainly related to edaravone can avoid endothelial cell injury,improve neurological function and inflammatory reaction,reduce leukocyte infiltration in infarction area.