成人应用伏立康唑的群体药动学研究进展

Research progress in population pharmacokinetics of voriconazole in adults

目的:伏立康唑抗真菌活性强,抗真菌谱广,但其药动学呈现高度变异性。本文基于群体药动学模型对伏立康唑的药动学特征进行描述,为伏立康唑的个体化用药提供理论依据。方法:通过对中国知网、Pubmed、Web of Science等数据库查找伏立康唑群体药动学研究文献进行汇总分析,描述伏立康唑药动学特征。结果:9篇文献报道伏立康唑的群体药动学模型为一房室模型,4篇文献为二房室模型。伏立康唑代谢的主要影响因素为年龄、体质量、CY2C19基因型、肝功能和合并用药。结论:伏立康唑个体间存在相当大的差异性。对于特殊人群,制定个性化给药方案尤为重要。

AIM:Voriconazole has strong antifungal activity and broad antifungal spectrum,but its pharmacokinetics is highly variable due to various factors.In this paper,the pharmacokinetic characteristics of voriconazole were described based on the population pharmacokinetic model,which provided a theoretical basis for the individualized use of voriconazole.METHODS:The pharmacokinetics of voriconazole was characterized by searching the literatures of voriconazole population pharmacokinetics in CNKI,Pubmed and Web of Science.RESULTS:Nine studies reported the PPK model of voriconazole was one-compartment models and 4 studies were two-compartment models.The main influencing factors of voriconazole pharmacokinetics were age,body weight,CY2C19 phenotype,liver function and concomitant medication.CONCLUSION:There is considerable variation between voriconazole individuals.For specific populations,it is especially important to develop a personalized dosing regimen.