高血压患者血清肌酸激酶hs-CRP脂蛋白a及同型半胱氨酸检测的临床价值

Clinical Value of Serum Creatine Kinase hs-CRP Lipoprotein a and Homocysteine in Hypertensive Patients

目的:研究高血压患者血清肌酸激酶、hs-CRP、脂蛋白a及同型半胱氨酸检测的临床价值。方法:选择2017年4月至2018年4月在我院接受治疗的高血压患者120例为高血压组,同期选择行正常体检的健康者100为对照组,检测两组血清CK、hs-CRP、Lp(a)、Hcy水平,采用ROC曲线分析CK、hs-CRP、Lp(a)、Hcy预测高血压中的临床价值。结果:高血压组血清CK、hs-CRP、Lp(a)、Hcy水平显著高于对照组,比较差异显著(P<0.05);经ROC曲线下面积分析,CK、hs-CRP、Lp(a)、Hcy预测高血压曲线下面积分别为0.638、0.781、0.725、0.731,其准确率分别为54.74%、75.45%、70.09%、69.09%;四者联合预测高血压的曲线下面积为0.878,准确率为83.18,均高于单独预测,比较差异显著(P<0.05)。结论:高血压患者血清CK、hs-CRP、Lp(a)、Hcy水平均显著升高,通过检测CK、hs-CRP、Lp(a)、Hcy对高血患者的治疗及预防均有重要的临床作用。

Objective:To study clinical value of serum creatine kinase,hs-CRP,lipoprotein a and homocysteine in hypertensive patients.Methods:120 patients of hypertension who received therapy from April 2017 and April 2018 in our hospital were selected as research objects as the high blood pressure group,the same choice in our normal physical examination of 100 patients of healthy subjects as control group,the detection of two groups of serum CK,hs-CRP,Lp(a),Hcy levels,using ROC curve analysis of CK,hs-CRP,Lp(a),Hcy predict clinical value in high blood pressure.Results:The serum CK,hs-crp,Lp(a)and Hcy levels of the high blood pressure group were significantly higher than those of the control group(P<0.05).According to the ROC curve analysis,the area under the hypertensive curve predicted by CK,hs-crp,Lp(a)and Hcy was 0.638,0.781,0.725,0.731.The accuracy rate was 54.74%,75.45%,70.09%,69.09%.The curve area of the four groups combined to predict hypertension was 0.878,and the accuracy rate was 83.18,both of which were higher than the single prediction,and the difference was significant(P<0.05).Conclusion:Serum CK,hs-crp,Lp(a)and Hcy levels of hypertensive patients were significantly increased,and the detection of CK,hs-crp,Lp(a)and Hcy had an important clinical effect on the treatment and prevention of hyperemia patients.