辅酶Q10注射液联合左卡尼汀对老年慢性肺源性心脏病并心功能不全的疗效分析

Exploring the Effect of Coenzyme Q10 Injection Combined with Levocarnitine on Elderly Patients with Chronic Pulmonary Heart Disease and Cardiac Insufficiency

目的:探讨辅酶Q10注射液联合左卡尼汀对老年慢性肺源性心脏病并心功能不全的疗效。方法:选择2015年1月至2018年5月我院接诊的老年慢性肺源性心脏病并心功能不全患者86例,随机数表法分为观察组45例和对照组41例,在常规治疗基础上,对照组给予左卡尼汀治疗,观察组在对照组基础上,联合辅酶Q10注射液治疗,均连续治疗3周。比较两组临床疗效、血液流变学、血气分析、心功能及不良反应。结果:治疗后,观察组临床疗效总有效率明显比对照组高(P<0.05);观察组全血粘度高切、全血粘度低切、血浆粘度、全血还原粘度均明显低于对照组(P<0.05);观察组血氧分压(PaO 2)明显高于对照组,二氧化碳分压(PaCO 2)明显低于对照组(P<0.05);观察组心率(HR)、左心室舒张末期内径(LVEDD)明显低于对照组,左室射血分数(LVEF)明显高于对照组,6min步行距离明显长于对照组(P<0.05);两组治疗期间不良反应差异无统计学意义(P>0.05)。结论:辅酶Q10注射液联合左卡尼汀用于老年慢性肺源性心脏病并心功能不全患者疗效显著,且安全性高。

Objective:To study the curative efficacy of coenzyme Q10 injection combined with levocarnitine in treatment of senior chronic pulmonary heart disease with cardiac insufficiency.Methods:86 patients of senior chronic pulmonary heart disease with cardiac insufficiency who received therapy from January 2015 to May 2018 in our hospital were selected as research objects,according to random number table,those patients were divided into the 45 cases of the observation group and 41 cases of the control group,on the basis of routine treatment,the control group was treated with levocarnitine,while the observation group was treated with coenzyme Q10 injection on the basis of the control group,they were treated for 3 weeks.The clinical efficacy,hemorheology,blood gas analysis,cardiac function and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of the observation group was significantly higher than those in the control group(P<0.05);The whole blood viscosity,high shear rate,low shear rate,plasma viscosity and whole blood reduced viscosity in the observation group were significantly lower than those in the control group(P<0.05);the partial pressure of oxygen(PaO 2)in the observation group was significantly higher than those in the control group,and the partial pressure of carbon dioxide(PaCO 2)in the observation group was significantly lower than those in the control group(P<0.05);the heart rate(HR)and left ventricular end-diastolic diameter(LVEDD)in the observation group were significantly lower than those in the control group,the left ventricular ejection fraction(LVEF)was significantly higher than those in the control group,and the 6-minute walking distance was significantly longer than those in the control group(P<0.05);there was no significant difference in adverse reactions between the two groups during treatment(P>0.05).Conclusion:Coenzyme Q10 injection combined with levocarnitine is well for senior chronic pulmonary heart disease with cardiac insufficiency,and has good drug safety.