承德地区妊娠早期妇女尿碘水平与甲状腺功能分析

Analysis of Urinary Iodine Level and Thyroid Function in Early Pregnancy Women in Chengde Area

目的:在已建立的承德地区妊娠特异性甲状腺指标参考范围的基础上,研究孕早期女性碘营养状况与甲状腺功能的相关性。方法:选取2017年1月至2017年12月于承德医学院附属医院产科门诊就诊的患者,共有2091例妊娠早期产妇符合筛选标准,检测其尿碘、血清TSH、FT3及FT4。最后用SPSS21.0系统对其进行数据分析,来探讨其相关性。结果:①承德地区孕妇尿碘中位数为132.1ug/L,属于碘缺乏状态。②碘适量组与碘缺乏组、碘超足量组、碘过量组甲状腺疾病的发生率存在显著差异(P<0.05),甲状腺疾病中低T4血症的的发生率有统计学差异(P<0.05)。③不同碘营养组间FT3和TSH无显著差异(P>0.05);碘适量及缺乏组FT4水平明显均高于碘超足量及过量组,差异均有统计学意义(P<0.05)。结论:从群体角度来看,承德地区大多数妊娠早期女性处于碘缺乏状态,应补充碘;同时应在孕前及孕早期进行甲状腺功能及碘营养状况的筛查,以便更好地对其进行孕期营养及用药指导。

Objective:To study the correlation between iodine nutrition status and thyroid function based on the established reference range of pregnancy specific thyroid indexes in Chengde area.Methods:In January 2017 to December 2017 showed there there were 2091 cases of pregnant women met the criteria,and their urine iodine,serum TSH,FT3 and FT4 were measured.Finally,the SPSS21.0 system is used to analyze the data to discuss its correlation.Results:①The median urinary iodine of pregnant women in Chengde area was 132.1 ug/L,belonging to iodine deficiency state.②There was a significant difference in the incidence of thyroid disease between iodine appropriate group and iodine deficiency group,iodine beyond appropriate group and iodine excess group(P<0.05),among the thyroid disease in low T4 concentration was statistically significant(P<0.05).③There was no significant difference in FT3 and TSH between the groups with different urinary iodine nutrition levels(P>0 05);The levels of FT4 in iodine deficiency group and iodine deficiency group were significantly higher than those in iodine beyond appropriate group and iodine excess group,and the differences were statistically significant.Conclusion:Most of women who are in the first trimester of pregnancy in Chengde area suffered an iodine deficiency and adequate supplementation of iodine should be taken into place,in the mean time,the screening of thyroid function should be popularized so as to provide a better guidance during pregnancy.