卒中后抑郁患者的脑区功能活动分析

Analysis for the brain region activities in patients with post-stroke depression

目的 应用静息态功能磁共振(rs-fMRI)检查探讨卒中后抑郁与非抑郁患者的脑区活动差异。方法 筛选符合入组标准的卒中后抑郁(PSD)患者22例(post-stroke depression,PSD组),急性缺血性卒中患者20例(对照组),2组患者均行静息态功能磁共振检查,比较2组患者基本资料及rs-fMRI低频振幅(ALFF)数值。结果 2组患者年龄、性别、血脂及受教育程度差异均无统计学意义(P>0.05);与对照组比较,PSD组患者右侧楔前叶(t=-3.23)、右侧扣带回(t=-2.72)及右侧距状裂周围皮层(t=-3.13)的ALFF值明显降低(P<0.05,AlphaSim矫正)。结论 PSD患者部分脑区功能活动下降。

Objective To investigate the differences of brain region activities between the patients with post-stroke depression(PSD)and the patients without PSD by resting state functional magnetic resonance(rs-fMRI)examination.Methods A total of 22 patients with PSD(PSD group)and 20 patients with acute ischemic cerebral stroke(control group)were enrolled in the study.The patients in both groups undrwent resting state function MRI examination.The clinical data,the amplitude of low frequency fluctuation(ALFF)and general information were observed and compared between the two groups.Results There were no significant differences in patient’s age and gender,blood lipids and education levels between the two groups(P>0.05).As compared with those in control group,the ALFF values in the right precuneus,the posterior cingulate cortex and cortex around the right calcarine fissure were significantly decreased in PSD group(P<0.05).Conclusion The neuronal activities are decreased in part brain region of patients with PSD.