植入前胚胎遗传学筛查对复发性流产患者妊娠结局的影响

The influence of preimplantation genetic screening on pregnancy outcomes of women with recurrent spontaneous abortion

目的:探讨胚胎植入前遗传学筛查技术对复发性流产患者妊娠结局的影响。方法:对复发性流产患者随机分组,对照组进行常规的体外受精胚胎移植,筛查组进行胚胎植入前遗传学筛查,比较两组妊娠结局。结果:筛查组40个治疗周期共活检212枚胚胎,其中整倍体胚胎115枚(54.2%),非整倍体胚胎97枚(45.8%);筛查组胚胎种植率和临床妊娠率(68.6%、35.3%)高于对照组(68.6%、52.8%),早期流产率(12.5%)低于对照组(26.3%)(P<0.05)。结论:对复发性流产患者行胚胎植入前遗传学筛查,选择整倍体胚胎移植,可提高种植率和临床妊娠率,降低早期流产率。

Objective:To explore the influence of preimplantation genetic screening on pregnancy outcomes of women with recurrent spontaneous abortion.Methods:The women with recurrent spontaneous abortion were divided into the study group and the control group randomly,and women in the study group had received preimplantation genetic testing and the women in the control group had received routine IVF embryo transfer.The pregnancy outcomes of women were compared between the two groups.Results:A total of 212 embryos of women in the study group were biopsied after 40 treatment cycles,which included 115(54.2%)euploid embryos and 97(45.8%)aneuploid embryos.The embryo implantation rate and clinical pregnancy rate of women in the study group were 68.8%and 68.6%,which were significant higher than those(35.3%and 52.8%)of women in the control group,the early abortion rate of women in the study group was 12.5%,which was significant lower than that(26.3%)of women in the control group(P<0.05).Conclusion:The selection of aneuploidy embryo transfer after preimplantation genetic screening for treating women with recurrent abortion can improve the implantation rate and clinical pregnancy rate,and can reduce early abortion.