妊娠期高血压患者血清HSP70、GATA-3、sFlt-1表达及意义

The expression and significance of serum levels of HSP 70, GATA 3 and sflt 1 of women with gestational hypertension

目的:探讨血清热休克蛋白70(HSP70)、细胞转录因子3(GATA 3)、可溶性血管内皮生长因子受体1(sFlt 1)在妊娠期高血压患者的表达及意义。方法:选择2016年2月—2017年2月本院接诊的妊娠期高血压患者80例为观察组,同期本院正常妊娠妇女60例为对照组,分析血清HSP70、GATA 3、sFlt 1水平变化。结果:观察组血清HSP70、sFlt 1水平高于对照组,GATA 3水平低于对照组,且观察组中仅妊娠期高血压患者HSP70、sFlt 1水平低于轻度子痫前期和重度子痫前期患者,GATA 3水平高于轻度子痫前期和重度子痫前期患者(P<0.05);相关性分析显示,HSP70、sFlt 11与妊娠期高血压、轻度子痫前期、重度子痫前期均呈正相关,GATA 3与妊娠期高血压、轻度子痫前期、重度子痫前期均呈负相关(P<0.05)。结论:在妊娠期高血压患者中HSP70、GATA 3、sFlt 1的表达与病情严重程度存在着密切关系,可为靶向药物治疗妊娠期高血压提供新思路。

Objective:To explore the expression and significance of serum levels of Heat shock protein 70(HSP 70),cell transcription factor 3(GATA 3),soluble vascular endothelial growth factor receptor 1(sflt 1)of women with gestational hypertension.Methods:80 women with gestational hypertension were selected in the observation group from February 2016 to February 2017,and 60 normal pregnant women were selected in control group.The levels of serum HSP 70,GATA 3 and sflt 1 of all women were analyzed.Results:The levels of serum HSP 70 and sflt 1 of women in the observation group were significant higher than those of women in the control group,but the GATA 3 level of women in the observation group was significant lower.In the observation group,the levels of HSP70 and sflt 1 of women without preeclampsia were significant lower than those of women with mild preeclampsia or severe preeclampsia,but the GATA 3 level of women without preeclampsia was significant higher(P<0.05).Correlation analysis showed that levels of HSP 70 and sflt 1 were positively correlated with the rate of women with gestational hypertension,mild preeclampsia,or severe preeclampsia,while GATA 3 level was negatively correlated with the rate of women with gestational hypertension,mild preeclampsia,or severe preeclampsia gestational hypertension,mild preeclampsia and severe preeclampsia(P<0.05).Conclusion:The expression of HSP70,GATA 3 and sflt 1 of pregnant women with gestational hypertension is closely related to the severity of the disease,which maybe provide a new idea for targeted drug treatment of gestational hypertension.