妊娠期糖尿病孕妇血清ApoA5水平与糖脂代谢

The relationship between the serum ApoA5 level and glycolipid metabolism of women with gestational diabetes mellitus

目的:探讨妊娠期糖尿病(GDM)患者血清载脂蛋白A5(ApoA5)水平与糖脂代谢的相关性。方法:选取2016年10月~2017年10月本院收治的GDM患者90例作为观察组,同期健康妊娠孕妇60例为对照组。取两组空腹静脉血,检测血清FBG、HbA1c、FINS、TC、TG、HDL C、LDL C、HOMA IR等糖脂生化指标及ApoA5水平并统计分析。结果:观察组TG、TC、FBG、FINS、HbA1c、ApoA5、HOMA IR高于对照组,HDL C、ApoAⅠ低于对照组(均P<0.05);Pearson相关分析,GDM患者血清中ApoA5与TG、TC、FBG、HOMA IR呈显著正相关(r=0.491、0.324、0.483、0.518,P<0.05),与HDL C呈显著负相关(r=0.313,P<0.05),与其他指标无显著相关(P>0.05);logistic多元回归分析,血清ApoA5、TG、TC、FBG及HOMA IR均是导致GDM发生发展的危险因素(P<0.05)。结论:GDM患者血清ApoA5的水平异常与疾病发生发展及糖脂代谢关系密切,可为GDM的诊治提供一定参考。

Objective:To investigate the relationship between the serum apolipoprotein A5(ApoA5)level and glycolipid metabolism of women with gestational diabetes mellitus(GDM).Methods:90 pregnant women with GDM were selected in observation group from October 2016 to October 2017,and 60 healthy pregnant women were selected in control group during the same period.The levels of serum FBG,HbA1c,FINS,TC,TG,HDL C,LDL C and ApoA5,and HOMA IR value of all included women were observed and were statistically analyzed.Results:The levels of TG,TC,FBG,FINS,HbA1c,ApoA5,and HOMA IR value of women in the observation group were significant higher than those of women in the control group,but the levels of HDL C of women in the observation group was significant lower(P<0.05).In the study group,Pearson correlation analysis showed that serum ApoA5 level was positively correlated with the levels of TG,TC,FBG,and value of HOMA IR value(r=0.491,0.324,0.483,0.518,P<0.05),the serum ApoA5 level was negatively correlated with level of HDL C(r=0.313,P<0.05),but the serum ApoA5 level was no correlated with levels of HbA1c,FINS,and LDL C(P>0.05).Logistic multivariate regression analysis showed that levels of serum ApoA5,TG,TC,FBG and value of HOMA IR were all risk factors for the occurrence and development of GDM(P<0.05).Conclusion:The abnormal level of serum ApoA5 of pregnant women with GDM is closely related to the occurrence and development of GDM and abnormal glycolipid metabolism,so it can provide evidence for diagnosing and treating GDM.