摘要
目的评价2014-2015年流感流行季流感疫苗在中小学生中集体接种后的保护效果。方法收集北京市2014年11-12月中小学生聚集性发热和流感样病例(ILI)疫情的病例信息和流感疫苗接种史,采用病例对照研究方法分析流感疫苗对ILI病例和实验室确诊流感病例的保护效果。结果 43所发生聚集性疫情的学校学生纳入本研究,实验室确诊流感病例组、ILI病例组、无症状对照组的流感疫苗接种率分别为38.9%(91/234)、36.7%(328/893)、39.7%(692/1 741);流感疫苗对ILI病例、实验室确诊流感病例的调整后保护效果分别为27%(95%CI:13%-39%)、7%(95%CI:-25%-31%)。结论在中小学生中开展流感疫苗集体接种对流感具有一定的保护效果。
Objective To examine the effectiveness of influenza vaccination of school children during the 2014-2015 season in Beijing. Methods We collected cases and influenza vaccination data in clusters of fever or influenza-like illness(ILI) during November-December 2014 in Beijing. We determined vaccine eff ectiveness(VE) of inf luenza vaccine against ILI and lab-confirmed influenza with a case-control study. Results The study included students f rom 43 schools with clusters of fever or ILI. Coverage rates of influenza vaccine were 38.9%(91/234), 36.7%(328/893), and 39.7%(692/1 741) among students in a lab-confirmed influenza case group, an ILI case group, and an asymptomatic control group, respectively. Adjusted VE estimates of influenza vaccine against ILI and laboratory-confirmed influenza were 27%(95%CI: 13%-39%) and 7%(95%CI:-25% to 31%), respectively. Conclusion Influenza vaccination of school students showed modest effectiveness against influenza.
作者
张莉
潘阳
马春娜
吴双胜
孙瑛
张漫
段玮
王全意
杨鹏
Zhang Li;Pan Yang;Ma Chunna;Wu Shuangsheng;Sun Ying;Zhang Man;Duan Wei;Wang Quanyi;Yang Peng(Institute for Infectious Disease and Endemic Disease Control,Beijing Municipal Center for Disease Control and Prevention/Beijing Center for Preventive Medicine Research,Beijing 100013,China;School of Public Health,Capital Medical University,Beijing 100069,China)
出处
《中国疫苗和免疫》
北大核心
2019年第4期423-426,共4页
Chinese Journal of Vaccines and Immunization
基金
首都卫生发展科研专项(2018-2-1013)
关键词
流感疫苗
保护效果
发热
流感样病例
聚集
Influenza vaccine
Vaccine effectiveness
Fever
Influenza-like illness
Clustering
