多囊卵巢综合征糖脂代谢异常对卵母细胞及胚胎发育影响的研究进展

Research progress on the influence of polycystic ovary syndrome glycolipid metabolism abnormality on oocyte and embryo development

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期妇女常见的内分泌紊乱性疾病,容易并发糖代谢异常、脂代谢异常、子宫内膜增生或癌症等.目前认为PCOS患者的血液或卵泡液中高浓度的葡萄糖会影响卵母细胞及胚胎的发育,而脂代谢物质的具体影响机制尚不明确.本文总结已发表文献来阐明PCOS患者的糖脂代谢异常对卵母细胞及胚胎发育的影响机制,以期为PCOS的诊断和治疗提供理论依据.

Polycystic ovary syndrome(PCOS)is a common endocrine disorder in women of reproductive age.It is easy to be complicated by abnormal glucose metabolism,abnormal lipid metabolism,endometrial hyperplasia or cancer.At present,it is believed that the high concentration of glucose in the blood or follicular fluid of PCOS patients will affect the development of oocytes and embryos,while the specific mechanism of the influence of lipid metabolites is still unclear.This paper summarizes published literatures to elucidate the influence mechanism of abnormal glucose and lipid metabolism on oocyte and embryo development in PCOS patients,so as to provide theoretical basis for the diagnosis and treatment of PCOS.