脑卒中后抑郁症患病率及相关因素分析

Post-stroke depression and related factors analysis

目的调查脑卒中后抑郁症(PSD)的患病率及其危险因素,为社区PSD防治提供理论依据。方法选择吉林大学第一医院神经内科2016年7月—2017年5月住院的脑卒中患者300例,采用SDS和汉密尔顿抑郁量表(HAMD)进行抑郁症评定,统计脑卒中后抑郁症发生情况,控制混杂因素后,用比值比(OR)和95%置信区间(CI)表示PSD与相关影响因素之间的关系。结果本组300例脑卒中患者中PSD患病率为31.6%(95/300)。在控制混杂因素后,发现婚姻状况、职业情况、活动能力下降、肌力水平、神经功能损伤程度、糖尿病与PSD患病率有相关性(P<0.05)。结论PSD患病率较高,与婚姻状况、职业情况、活动能力下降、肌力水平、神经功能损伤程度和糖尿病等多种因素密切相关。对于PSD危险因素的认识,有助于临床PSD的预防和治疗提供干预手段,对于降低PSD患病率和提高PSD患者身体功能能力具有一定作用。

Objective To investigate the incidence of post-stroke depression(PSD)and its risk factors,so as to provide the theoretical reference for the prevention of community PSD.Methods A total of 300 stroke patients hospitalized in the department of neurology in the First Bethune Hospital of Jilin University from July 2016 to May 2017 were selected and assessed by Self-rating Depression Scale(SDS)and Hamilton Depression Scale(HAMD)on their depression.The incidence of PSD was analyzed and after controlling the confounding factors,the relation between PSD and relevant influencing factors were indicated by the Odds Ratio(OR)and 95%Confidence Interval(CI).Results The incidence of PSD was 31.6%(95/300)in the 300 stroke patients.After controlling the confounding factors,it was found that marital status,occupational status,decreased activity ability,muscle strength,neurological impairment and diabetes were closely related to PSD(P<0.05).Conclusions The prevalence of PSD is high and closely related to marital status,occupational status,decreased activity ability,muscle strength,neurological impairment and diabetes.Understanding the risk factors of PSD is necessary to provide intervention for the prevention and treatment of PSD,which has a certain effects in reducing PSD and improving the PSD patients'physical function.