认知功能在房颤患者负性情绪与生命质量间的调节效应和中介效应

Moderating and mediating effect of cognitive function between negative emotion and quality of life in patients with atrial fibrillation

目的探讨认知功能在房颤患者负性情绪与生命质量间的调节效应和中介效应。方法采用便利抽样法选取2017年12月—2018年5月在天津市某三甲医院住院的222例房颤患者作为研究对象,采用医院焦虑抑郁量表(HADS)、北京版蒙特利尔认知评估量表(MoCA)、心房颤动患者生命质量量表(AF-QoL-18)对其进行调查。本研究共发放问卷222份,回收有效问卷200份。结果"认知功能×负性情绪"交互作用项的偏回归系数β值为-0.184,P<0.001,且引入交互作用项后新增解释量亦有统计学意义(ΔR2=0.026,P<0.001)。认知功能在负性情绪和生命质量间的部分中介效应显著,且基准模型拟合良好。多群组分析结果显示基准模型在不同性别人群间具有不变性。结论认知功能在房颤患者负性情绪与生命质量间起调节及部分中介作用,且无性别差异。

Objective To explore the moderating effect and mediating effect of cognitive function between negative emotion and quality of life in patients with atrial fibrillation(AF).Methods Totally 222 AF patients hospitalized in a ClassⅢGrade A hospital in Tianjin from December 2017 to May 2018 were selected by convenience sampling method.Hospital Anxiety and Depression Scale(HADS),Beijing version of Montreal Cognitive Assessment Scale(MoCA),and Atrial Fibrillation Quality of Life Scale(AF-QoL-18)were used in the investigation.A total of 222 questionnaires were sent out and 200 valid ones were collected.Results The partial regression coefficient of the interaction item of"cognitive function*negative emotion"was-0.184,P<0.001,and the new explanatory amount after introducing the interaction item had statistical significance(ΔR2=0.026,P<0.001).Cognitive function had a significant mediating effect between negative emotions and quality of life,and the benchmark model fitted well.The results of multi-group analysis showed that the benchmark model was invariant among different gender groups.Conclusions Cognitive function had regulating and partial mediating effects between negative emotion and quality of life in patients with AF and there shows no difference between different genders.