炎性细胞因子作为淋巴瘤生物标志物和分子靶点的研究进展

Progress of inflammatory cytokines as lymphoma biomarkers and molecular targets

炎症反应存在于大多数疾病的发展过程中,近年来,肿瘤相关炎症反应在肿瘤微环境中的作用逐渐受到重视.炎症反应可促进局部淋巴瘤发生,同时淋巴瘤细胞的生长、增殖亦依赖于炎性肿瘤微环境,炎症反应在淋巴瘤的发生、发展及治疗过程中具有重要作用.炎性细胞因子是炎症介质的主要类别,其表达水平反映机体的炎症反应状态,具有作为淋巴瘤生物标志物和分子靶点的潜力.

The inflammatory response is involved in the development of most diseases. In recent years, tumor associated inflammatory response in tumor microenvironment has been paid more attention. Inflammation promotes the progress of lymphoma, and the growth and proliferation of lymphoma cells also depend on the inflammatory tumor microenvironment. Inflammatory response plays an important role in the development and treatment of lymphoma. Inflammatory cytokines are main types of inflammatory mediators, their expression levels reflect the inflammatory response state of the body, and have potential to be biomarkers and molecular targets of lymphoma.