温润辛金培本膏方对慢性阻塞性肺疾病患者营养状况及生活质量的影响

Effect of Wenrun-Xinjin-Peiben paste on nutritional status, quality of life of chronic obstructive pulmonary disease

目的探讨温润辛金培本膏方对COPD稳定期患者营养状况及生活质量的影响.方法将符合入选标准的94例COPD稳定期合并营养不良患者按随机数字表法分为2组,每组47例.对照组采用常规疗法治疗,治疗组在对照组基础上服用温润辛金培本膏方.2组均治疗6个月.观察治疗前后患者的营养状况并进行中医证候评分;采用全血细胞分析仪检测血红蛋白、全自动生化分析仪检测白蛋白及前白蛋白,采用肺功能血氧仪测定FEV1,采用圣乔治呼吸问卷(St.George's Respiratory Questionnaire,SGRQ)评估患者生活质量受疾病影响的程度,评价临床疗效.结果治疗组总有效率为90.5%(38/42)、对照组为61.9%(26/42),2组比较差异有统计学意义(Z=3.173,P=0.002).治疗组治疗后BMI、三头肌厚度、上臂围均较同组治疗前增加(t值分别为2.407、2.024、2.138,P<0.05),但组间比较差异无统计学意义(P>0.05).治疗后,治疗组血红蛋白[(135.69±16.42)g/L比(122.75±14.99)g/L,t=12.346]、白蛋白[(35.89±6.14)g/L比(33.01±6.20)g/L,t=2.139]水平均高于对照组(P<0.01或P<0.05);治疗组疾病影响评分[(24.9±16.1)分比(36.6±16.9)分,t=3.252]及总分[(41.4±14.9)分比(48.0±14.9)分,t=2.006]均低于较对照组(P<0.05);治疗组FEV1[(65.22±4.01)%比(60.17±4.34)%,t=5.538]高于对照组(P<0.01).结论温润辛金培本膏方联合西医常规疗法有助于提高COPD稳定期患者的营养状况,改善生活质量.

Objective To explore the effect of Wenrun-Xinjin-Peiben paste on the nutrition status, quality of life and pulmonary function in the stable COPD patients. Methods A total of 94 malnutrition patients with stable COPD were randomly divided into treatment group (47 cases) and control group (47 cases). The patients in the control group took Symbicort 1 suction/time, bid, and the patients were given oxygen therapy, health and diet nutrition education. The patients in the treatment group were given Wenrun-Xinjin-Peiben paste 6 months as well as the control group treatment. The nutritional status (body mass index, triceps skinfold thickness, upper arm circumference, hemoglobin, albumin, prealbumin), quality of life and pulmonary function in the two groups were compared. Results The curative effect of TCM syndromes was 90.48% in the treatment group, which is significantly higher than 61.90 % in the control group (Z=3.173, P=0.002). The hemoglobin in the treatment group was superior to the control group (135.69 ± 16.42 g/L vs. 122.75 ± 14.99 g/L;t=12.346, P<0.001). The Albumin in the treatment group was superior to the control group (35.89 ± 6.14 g/L vs. 33.01 ± 6.20 g/L;t=2.139, P=0.035). The disease impacts domain of ST George's respiratory questionnaire in the treatment group was superior to the control group (24.9 ± 16.1 vs. 36.6 ± 16.9;t=3.252, P=0.002). Total score of ST George's respiratory questionnaire in the treatment group was superior to the control group (41.4 ± 14.9 vs. 48.0 ± 14.9;t=2.006, P=0.048). The FEV1 predicted value in the treatment group was superior to the control group (65.22% ± 4.01% vs. 60.17% ± 4.34%;t=5.538, P=0.000). Conclusions The Wenrun-Xinjin-Peiben paste combined with western medicine could help to improve the nutritional status and quality of life of patients in stable COPD.