术前全身免疫炎症指数对胃癌患者预后的影响

Effect of preoperative systemic immune-inflammation index on the prognosis of patients with gastric cancer

目的观察术前全身免疫炎症指数(SII)与胃癌患者临床病理特征的相关性及其对患者预后的影响。方法回顾性分析2008年1月~2015年8月于济南市中心医院行手术切除并经病理诊断为胃癌的175例患者的术前SII与术后临床病理参数及患者预后的相关性。采用SPSS17.0软件进行统计学分析。采用受试者工作特征曲线(ROC)、卡方检验、COX比例风险模型、Kaplan Meier法、log-rank检验分析数据。结果随访175例患者生存分析显示:1年、3年、5年生存率为81%,59%,51%.中位生存时间66.55个月。SII≥782×10^9/L与N分期(淋巴结转移)、肿瘤大小、TNM分期呈正相关(P<0.05)。单因素分析示:肿瘤大小、T分期、N分期、TNM分期、SII为影响胃癌预后的危险因素(P<0.05)。多因素分析示:SII为影响胃癌预后的独立因素(HR=0.570,95%CI:0.364-0.893,P=0.014)。结论术前SII的检测对于评价胃癌患者的预后有意义。

Objective To investigate the correlation between preoperative Systemic immune-inflammation index(SII) and clinicopathological features of patients with gastric cancer and its influence on prognosis.Methods This study retrospectively analyzed the clinicopathological data and prognostic information of 175 patients who underwent surgical resection and pathological diagnosis of gastric cancer from January 2008 to August 2015 in Jinan Central Hospital.Statistical analysis was performed using SPSS17.0 software.Data were analyzed using receiver operating characteristic curve(ROC),chi-square test,COX proportional hazard model,Kaplan Meier method,and log-rank test.Results Survival analysis of 175 patients was followed up:the 1-year,3-year,and 5-year survival rates were 81%,59%,and 51%.The median survival time was 66.55 months.SII≥782×10^9/L was associated with N stage(lymph node metastasis),tumor size,and TNM stage(P<0.05).Univariate analysis showed that tumor size,T stage,N stage,TNM stage,preoperative SII were risk factors for the prognosis of gastric cancer(P<0.05).Multivariate analysis showed that SII was an independent factor affecting the prognosis of gastric cancer(HR=0.570,95%CI:0.364-0.893,P=0.014).Conclusion Preoperative detection of SII is of great significance in evaluating the prognosis of patients with gastric cancer.