中西医结合治疗糖尿病性腹泻随机对照试验的Meta分析

Meta Analysis of Randomized Controlled Trial of Diabetic Diarrhea Treated by Combination of Traditional Chinese and Western Medicine

目的:通过Meta分析系统评价中西医结合治疗糖尿病性腹泻(Diabetic diarrhea,DD)的临床疗效。方法:通过计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据库、中国生物医学文献数据库(CBM),收集中西医结合治疗糖尿病性腹泻的随机对照试验(RCT),按照纳入标准和排除标准对文献进行筛选和数据提取,并使用改良后的Jadad量表进行质量评分。运用Rev Man 5.3软件对提取数据进行Meta分析,比较中西医结合疗法与单纯的西医疗法治疗糖尿病性腹泻的临床有效率,以及治疗后糖代谢指标[空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)]、胃肠动力指标[口-结肠转运时间(OCTT)、生长抑素(SS)、胃泌素(GAS)、胃动素(MOT)]的变化。结果:共纳入13个随机对照试验,共953例患者,Meta分析结果显示,与西医对照组相比,中西医结合治疗糖尿病性腹泻的临床疗效优于单纯的西医治疗,差异具有统计学意义(P<0.05);治疗后FPG、2hPG、OCTT、SS、GAS差异具有统计学意义(P<0.05);治疗后HbA1c、MOT差异不具有统计学意义(P≥0.05)。结论:中西医结合治疗糖尿病性腹泻的临床疗效优于单纯的西药治疗,可有效改善患者腹泻情况并可降低血糖、改善胃肠道动力指标水平,减轻肠道反应。因此,在临床上可以推广使用中西医结合疗法治疗糖尿病性腹泻,更好地缓解患者症状,提高患者生活质量。

Objective:The clinical efficacy of Chinese and Western medicine in the treatment of diabetic diarrhea(Diabetic diarrhea,DD)was evaluated by Meta analysis system.Methods:By computer searching the Chinese Journal Full Text Database(CNKI),The Vipe Chinese Science and Technology Journal Full Text Database(VIP),the Wanfang Database,the Chinese Biomedical Literature Database(CBM),and collecting randomized controlled trials(RCTs)of Chinese and Western medicine in combination with the treatment of diabetic diarrhea,The literature was screened and extrac ted according to the inclusion criteria and the exclusion criteria,and the quality score was carried out using the improved Jadad scale.Meta analysis of extracted data using Rev Man 5.3 software,comparing the clinical efficiency of Chinese and Western medicine combination therapy with simple Western medical treatment for diabetic diarrhea,as well as post-treatment sugar metabolism indicators(FPG),2 hours blood sugar(2hPG),glycated hemoglobin(HbA1c),Changes in gastrointestinal dynamics(mouth-colon transport time(OCTT),growth inhibitor(SS),gastrointestinal progenitor(GAS),gastric kinesin(MOT).Results:A total of 13 randomized controlled trials were included in 953 patients,and the results of Meta analysis showed that the overall curative effect of combination of traditional Chinese and western medicine on diabetic diarrhea was better than that of Western medicine control group,and the difference was statistically significant(P<0.05).After treatment FPG,2hPG,OCTT,SS,The difference of GAS was statistically significant(P<0.05),and the difference of HbA1c and MOT after treatment was not statistically significant(P≥0.05).Conclusion:The clinical efficacy of Chinese and Western medicine in combination with the treatment of diabetic diarrhea is better than that of simple Western medicine,which can effectively improve the diarrhea condition of patients and reduce blood sugar,improve the level of gastrointestinal dynamic index,and reduce the intestinal response.Therefore,in the clinical can promote the use of Chinese and Western medicine combined therapy to treat diabetic diarrhea,better alleviate the symptoms of patients,improve the quality of life of patients.