鼻塞式持续气道正压通气联合小剂量多巴胺治疗重症毛细支气管炎患儿的临床效果

Clinical effects of nasal continuous positive airway pressure combined with low-dose Dopamine on children with severe bronchiolitis

目的:探究鼻塞式持续气道正压通气(NCPAP)联合小剂量多巴胺治疗重症毛细支气管炎患儿的临床效果。方法:选取重症毛细支气管炎患儿96例,按照不同治疗方法分为观察组和对照组,每组48例。对照组予NCPAP治疗,观察组在对照组基础上予小剂量多巴胺治疗。比较两组临床疗效,症状改善情况及治疗前后动脉血二氧化碳分压(PaCO_2)、动脉血氧分压(PaO_2)及pH值水平。结果:观察组治疗有效率为91.67%,高于对照组的75.00%,差异有统计学意义(P<0.05);观察组喘憋、咳嗽、肺啰音等症状消失时间及心率、呼吸恢复正常时间均短于对照组,差异有统计学意义(P<0.05);治疗后观察组PaCO_2水平低于对照组,PaO_2、pH水平高于对照组,差异有统计学意义(P<0.05)。结论:NCPAP联合小剂量多巴胺治疗重症毛细支气管炎患儿疗效较好,可有效缓解临床症状,改善患儿呼吸状况。

Objective:To investigate clinical effects of nasal continuous positive airway pressure(NCPAP)combined with low-dose Dopamine on children with severe bronchiolitis.Methods:96 children with severe bronchiolitis admitted to our hospital were divided into two groups according to the treatment plan.The control group(n=48)was treated with NCPAP,while the observation group(n=48)was treated with lowdose Dopamine on the basis of that of the control group.The clinical efficacy,symptom improvement,arterial blood carbon dioxide partial pressure(PaCO2),arterial oxygen partial pressure(PaO2)and pH levels were compared between the two groups.Results:The effective rate of the observation group was 91.67%,which was higher than that of the control group(75.00%)(P<0.05).The time of disappearance of symptoms such as wheezing,cough and lung rales as well as the time for recovering the normal heart rate and respirator rate of the observation group were shorter than those of the control group(P<0.05).After the treatment,the level of PaCO2 in the observation group was lower than that in the control group,and the level of PaO2 and pH were higher than that in the control group(P<0.05).Conclusions:NCPAP combined with low-dose Dopamine in the treatment of the children with severe bronchiolitis has a significant effect.It can effectively alleviate the clinical symptoms and improve the respiratory status of these children.