特发性震颤诊疗进展

Advance in diagnosis and treatment of essential tremor

以往将特发性震颤(ET)作为一种孤立性单症状性疾病,现在越来越多的研究证明ET可能是一种神经退行性变,呈慢性进行性病程,其临床表现不仅限于运动症状,还包括认知功能障碍、情感反应异常等,ET影响患者的注意力、执行力、记忆力等高级神经皮层功能,且ET患者多合并情绪障碍如焦虑症、抑郁症等。ET病变广泛,涵盖了神经影像、神经电生理、神经病理、情感认知等不同方面的改变。本文结合近年文献,就ET近年的诊疗进展等展开综述。

Essential tremor(ET)is traditionally defined as a monosymptomatic disorder has been questioned,as there is increasing evidence that it is not a unique entity,but a slowly progressive neurodegenerative disorder,it is often associated with cognitive deficits and emotional disorders,cognitive function such as the ability of attention,executive functions,memory decreased in ET,and the patients always suffered from depression and anxiety,the ET disease itself involved the abnormality of neuroimaging,electrophysiological,pathological studies,cognitive and mood function.This paper reviewed the recently progress of ET in diagnosis and treatment.