白鬼笔蘑菇菌丝体多糖：免疫调节和伤口愈合特性（英文）

Polysaccharides of Mushroom Phallus impudicus Mycelium: Immunomodulating and Wound Healing Properties

白鬼笔蘑菇在亚洲和北欧是一种传统的民间医药。本文综述了我们人工培养白鬼笔菌丝体的研究成果,以及从白鬼笔菌丝体中分离出的多糖的生物活性数据。对白鬼笔新菌株菌丝体的培养形态特征和生理生化特性进行了研究。经过优化培养基的营养物构成和培养条件能够使菌体生物量提高1.3倍,多糖含量提高1.5~1.7倍。从该菌丝体中分离的多糖在体外和在体内(链脲佐菌素诱导的糖尿病大鼠)均具有免疫调节作用。与原始软膏相比,含有10%白鬼笔多糖的软膏,能促进实验大鼠的皮肤创面愈合,促进肉芽组织的上皮形成、收缩和生长。综上所述,白鬼笔菌丝体多糖有望成为开发功能性食品以及新型治疗和预防药物的原材料。

Mushroom Phallus impudicus is traditionally used in Asia and Northern Europe as a remedy of folk medicine.This review summarizes our own results on the artificial cultivation of the P.impudicus mycelium and some data on the study of the biological activity of polysaccharides isolated from this mycelium.The cultural-morphological and physiological-biochemical properties of the mycelium of the new fungal strain of P.impudicus were studied.The optimization of the nutrient medium composition and cultural conditions enabled to increase the biomass yield by 1.3-fold,and the contents of polysaccharides by 1.5 to 1.7-fold.The polysaccharides isolated from this mycelium possessed immunomodulating properties in vitro as well as in vivo in experimental rats with streptozotocin-induced diabetes.The ointment containing 10%P.impudicus polysaccharides enhanced cutaneous wound healing in experimental rats,accelerating epithelialization,contraction and growth of granulation tissue as compared to the ointment base.Taken together,polysaccharides of P.impudicus mycelium are promising raw material for the development of functional food as well as new therapeutic and prophylactic drugs.